Beckman Laser Institute Korea, Dankook University, Cheonan 31116, Republic of Korea.
Department of Otolaryngology-Head &Neck Surgery, College of Medicine, Dankook University, Cheonan 31116, Republic of Korea.
Int J Mol Sci. 2023 Oct 21;24(20):15427. doi: 10.3390/ijms242015427.
Photobiomodulation (PBM) is the regulation of biological processes using light energy from sources such as lasers or light-emitting diodes. Components of the nervous system, such as the brain and peripheral nerves, are important candidate PBM targets due to the lack of therapeutic modalities for the complete cure of neurological diseases. PBM can be applied either to regenerate damaged organs or to prevent or reduce damage caused by disease. Although recent findings have suggested that neural cells can be regenerated, which contradicts our previous understanding, neural structures are still thought to have weaker regenerative capacity than other systems. Therefore, enhancing the regenerative capacity of the nervous system would aid the future development of therapeutics for neural degeneration. PBM has been shown to enhance cell differentiation from stem or progenitor cells to near-target or target cells. In this review, we have reviewed research on the effects of PBM on neurogenesis in the central nervous system (e.g., animal brains) and the peripheral nervous system (e.g., peripheral sensory neural structures) and sought its potential as a therapeutic tool for intractable neural degenerative disorders.
光生物调节（PBM）是利用激光或发光二极管等光源的光能来调节生物过程。神经系统的组成部分，如大脑和周围神经，是 PBM 的重要候选目标，因为目前还没有治疗神经疾病的完全治愈方法。PBM 既可以用于再生受损器官，也可以用于预防或减少疾病引起的损伤。尽管最近的研究结果表明神经细胞可以再生，这与我们以前的理解相矛盾，但人们仍然认为神经结构的再生能力比其他系统弱。因此，增强神经系统的再生能力将有助于未来开发治疗神经退行性疾病的药物。研究表明，PBM 可以促进干细胞或祖细胞向接近靶细胞或靶细胞的分化。在这篇综述中，我们回顾了 PBM 对中枢神经系统（如动物大脑）和周围神经系统（如周围感觉神经结构）中神经发生的影响，并探讨了其作为治疗难治性神经退行性疾病的潜在工具的可能性。
