Clark J H, Fitzgerald J F, Bergstein J M
J Pediatr Gastroenterol Nutr. 1985 Oct;4(5):829-34. doi: 10.1097/00005176-198510000-00026.
Six children with inflammatory bowel disease and nephrolithiasis are reported. Their mean age at the passage of the first stone was 12.5 years and the mean duration of active inflammatory bowel disease was 34.5 months. Four had ulcerative colitis and two had Crohn's disease. In three patients, the onset of stone disease was associated with a flare in the bowel disease. Stone passage in four patients was accompanied by an increase in abdominal pain; three experienced gross hematuria. Stones from four of the patients were composed primarily of calcium phosphate; stones from the remaining patients contained uric acid and/or calcium oxalate. The pathogenesis of nephrolithiasis as it relates to inflammatory bowel disease is considered and an approach to therapy offered.
报告了6例患有炎症性肠病和肾结石的儿童。他们首次排出结石时的平均年龄为12.5岁，活动性炎症性肠病的平均病程为34.5个月。4例患有溃疡性结肠炎，2例患有克罗恩病。在3例患者中，结石病的发作与肠道疾病的发作有关。4例患者排出结石时伴有腹痛加剧；3例出现肉眼血尿。4例患者的结石主要由磷酸钙组成；其余患者的结石含有尿酸和/或草酸钙。文中讨论了与炎症性肠病相关的肾结石发病机制并提供了治疗方法。
