Böhles H, Beifuss O J, Brandl U, Pichl J, Akçetin Z, Demling L
Abteilung Pädiatrie, Universität Erlangen.
Klin Wochenschr. 1988 Feb 1;66(3):87-91. doi: 10.1007/BF01774220.
An increased frequency of kidney stone formation is reported in patients with inflammatory bowel disease. In order to investigate its pathogenesis, the concentrations of factors known to enhance calcium oxalate stone formation (oxalate, calcium, uric acid) as well as of inhibitory factors for nephrolithiasis (magnesium, citrate) were determined in the urine of 86 patients with Crohn's disease and compared with those of 53 metabolically healthy controls. Six patients with Crohn's disease already had experienced calcium oxalate nephrolithiasis. Patients with Crohn's disease had significantly higher urinary oxalate and lower magnesium and citrate concentrations. Among all patients magnesium and citrate were significantly lower in those with a positive history of kidney stones. Our results demonstrate that the increased propensity for renal stone formation in patients with Crohn's disease is a result not only of increased urinary oxalate, but also of decreased urinary magnesium and citrate concentrations.
据报道，炎症性肠病患者肾结石形成的频率增加。为了研究其发病机制，测定了86例克罗恩病患者尿液中已知可促进草酸钙结石形成的因子（草酸盐、钙、尿酸）以及肾结石抑制因子（镁、柠檬酸盐）的浓度，并与53名代谢健康的对照者进行了比较。6例克罗恩病患者已经经历过草酸钙肾结石。克罗恩病患者的尿草酸盐显著升高，而镁和柠檬酸盐浓度降低。在所有患者中，有肾结石阳性病史的患者镁和柠檬酸盐明显较低。我们的结果表明，克罗恩病患者肾结石形成倾向增加不仅是尿草酸盐增加的结果，也是尿镁和柠檬酸盐浓度降低的结果。
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