Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA.
Mathematics Group, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
Phys Rev Lett. 2018 Jun 15;120(24):248003. doi: 10.1103/PhysRevLett.120.248003.
Active stresses can cause instabilities in contractile gels and living tissues. Here we provide a generic hydrodynamic theory that treats these systems as a mixture of two phases of varying activity and different mechanical properties. We find that differential activity between the phases causes a uniform mixture to undergo a demixing instability. We follow the nonlinear evolution of the instability and characterize a phase diagram of the resulting patterns. Our study complements other instability mechanisms in mixtures driven by differential adhesion, differential diffusion, differential growth, and differential motion.
活性应力会导致收缩凝胶和活体组织产生不稳定性。在这里,我们提供了一种通用的流体动力学理论,将这些系统视为具有不同活性和机械性能的两个相的混合物。我们发现,相之间的活性差异会导致均匀混合物发生相分离不稳定性。我们跟踪了不稳定性的非线性演化,并对所产生模式的相图进行了特征描述。我们的研究补充了由差异黏附、差异扩散、差异生长和差异运动驱动的混合物中的其他不稳定性机制。