Sarver Heart Center, University of Arizona, Tucson.
Cardiovascular Performance Program, Massachusetts General Hospital, Boston.
Am J Med. 2018 Nov;131(11):1279-1284. doi: 10.1016/j.amjmed.2018.05.037. Epub 2018 Jun 26.
Routine moderate-intensity physical activity confers numerous cardiovascular benefits and reduces all-cause mortality. However, the health impact of exercise doses that exceed contemporary physical activity guidelines remains incompletely understood, and an emerging body of literature suggests that high levels of exercise may have the capacity to damage the cardiovascular system. This review focuses on the contemporary controversies regarding high-dose exercise and cardiovascular morbidity and mortality. We discuss the limitations of available studies, explore potential mechanisms that may mediate exercise-related cardiac injury, and highlight the gaps in knowledge for future research.
常规的中等强度体育活动可带来诸多心血管益处，并降低全因死亡率。然而，运动剂量超过当代体力活动指南所带来的健康影响仍不完全清楚，而且越来越多的文献表明，高水平的运动可能有损伤心血管系统的能力。本综述重点讨论了关于大剂量运动与心血管发病率和死亡率的当代争议。我们讨论了现有研究的局限性，探讨了可能介导与运动相关的心脏损伤的潜在机制，并强调了未来研究的知识空白。
