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老年患者反复跌倒及抗凝治疗的影响

Recurrent Falls Among Elderly Patients and the Impact of Anticoagulation Therapy.

作者信息

Chiu Alexander S, Jean Raymond A, Fleming Matthew, Pei Kevin Y

机构信息

Department of Surgery, Yale School of Medicine, New Haven, CT, USA.

National Clinician Scholars Program, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.

出版信息

World J Surg. 2018 Dec;42(12):3932-3938. doi: 10.1007/s00268-018-4728-1.

Abstract

BACKGROUND

Falls are the leading source of injury and trauma-related hospital admissions for elderly adults in the USA. Elderly patients with a history of a fall have the highest risk of falling again, and the decision on whether to continue anticoagulation after a fall is difficult. To inform this decision, we evaluated the rate of recurrent falls and the impact of anticoagulation on outcomes.

METHODS

All patients of age  ≥ 65 years and hospitalized for a fall in the first 6 months of 2013 and 2014 were identified in the nationwide readmission database, a nationally representative all-payer database tracking patient readmissions. Readmissions for a recurrent fall within 6 months, and mortality and bleeding injuries (intracranial hemorrhage, solid organ bleed, and hemothorax) during readmission were identified. Logistic regression evaluated factors associated with mortality on repeat falls.

RESULTS

Of the 331,982 patients admitted for a fall, 15,565 (4.7%) were admitted for a recurrent fall within 6 months. The median time to repeat fall was 57 days (IQR 19-111 days), and 9.0% (1406) of repeat fallers were on anticoagulation. The rate of bleeding injury was similar regardless of anticoagulation status (12.8 vs. 12.7% not on anticoagulation, p = 0.97); however, among patients with a bleeding injury, those on anticoagulation had significantly higher mortality (21.5 vs. 6.9% not on anticoagulation, p < 0.01).

CONCLUSION

Among patients hospitalized for a fall, 4.7% will be hospitalized for a recurrent fall within 6 months. Patients on anticoagulation with repeat falls do not have increased rates of bleeding injury but do have significantly higher rates of death with a bleeding injury. This information is essential to discuss with patients when deciding to restart their anticoagulation.

摘要

背景

在美国,跌倒为老年人受伤及因创伤入院的首要原因。有跌倒史的老年患者再次跌倒的风险最高,跌倒后是否继续抗凝治疗的决策颇具难度。为辅助这一决策,我们评估了再次跌倒的发生率以及抗凝治疗对结局的影响。

方法

在全国再入院数据库中确定了所有年龄≥65岁且在2013年和2014年前6个月因跌倒住院的患者,该数据库是一个具有全国代表性的跟踪患者再入院情况的全付费者数据库。确定了6个月内再次跌倒的再入院情况,以及再入院期间的死亡率和出血性损伤(颅内出血、实体器官出血和血胸)。逻辑回归评估了与再次跌倒时死亡率相关的因素。

结果

在331,982例因跌倒入院的患者中,15,565例(4.7%)在6个月内因再次跌倒入院。再次跌倒的中位时间为57天(四分位间距19 - 111天),9.0%(1406例)再次跌倒的患者正在接受抗凝治疗。无论抗凝状态如何,出血性损伤的发生率相似(未接受抗凝治疗者为12.8% vs. 12.7%,p = 0.97);然而,在有出血性损伤的患者中,接受抗凝治疗者的死亡率显著更高(未接受抗凝治疗者为6.9% vs. 21.5%,p < 0.01)。

结论

在因跌倒住院的患者中,4.7%会在6个月内因再次跌倒住院。再次跌倒且接受抗凝治疗的患者出血性损伤发生率并未增加,但出血性损伤时的死亡率显著更高。在决定重新开始抗凝治疗时,这些信息对于与患者讨论至关重要。

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