López Marisa, Ríos-Silva Mónica, Huerta Miguel, Cárdenas Yolitzy, Bricio-Barrios Jaime Alberto, Díaz-Reval María Irene, Urzúa Zorayda, Huerta-Trujillo Miguel, López-Quezada Karla, Trujillo Xóchitl
1 Universidad de Colima, Unidad de Investigación Dr. Enrico Stefani, Centro Universitario de Investigaciones Biomédicas, Col. Villas San Sebastián, Colima, México.
2 Universidad de Colima-Cátedras CONACyT, Centro Universitario de Investigaciones Biomédicas, Col. Villas San Sebastián, Colima, México.
J Int Med Res. 2018 Aug;46(8):3327-3336. doi: 10.1177/0300060518781726. Epub 2018 Jul 1.
Objective To evaluate the preventive effects of Moringa oleifera on metabolic syndrome (MS) in male Wistar rats. Methods MS was induced by feeding rats a high-fat diet and drinking water containing 10% fructose for 6 weeks. In the preventive group, M. oleifera was orally administered for 3 weeks prior to the induction of MS, while in the treatment group, M. oleifera was administered for 3 weeks after the onset of MS. The treatment groups were compared with a control group of untreated rats with induced MS. Fasting glucose, oral glucose tolerance, insulin tolerance, total cholesterol, triglycerides, abdominal circumference, and systolic and diastolic blood pressure were measured before and after MS induction and/or M. oleifera treatment. Results After the induction of MS, the control group had higher fasting glucose levels than the preventive group. No significant differences were observed in insulin tolerance, oral glucose tolerance, cholesterol, triglycerides, abdominal circumference, or systolic or diastolic blood pressure. Compared with untreated controls, rats in the treatment group had significantly improved glucose tolerance, triglycerides, and abdominal circumference. Conclusions M. oleifera treatment attenuates MS in Wistar rats.
目的 评估辣木对雄性Wistar大鼠代谢综合征（MS）的预防作用。方法 通过给大鼠喂食高脂饮食并饮用含10%果糖的水6周来诱导MS。在预防组中，在诱导MS前3周口服辣木，而在治疗组中，在MS发病后3周给予辣木。将治疗组与诱导MS的未治疗大鼠对照组进行比较。在MS诱导和/或辣木治疗前后测量空腹血糖、口服葡萄糖耐量、胰岛素耐量、总胆固醇、甘油三酯、腹围以及收缩压和舒张压。结果 诱导MS后，对照组的空腹血糖水平高于预防组。在胰岛素耐量、口服葡萄糖耐量、胆固醇、甘油三酯、腹围或收缩压或舒张压方面未观察到显著差异。与未治疗的对照组相比，治疗组大鼠的葡萄糖耐量、甘油三酯和腹围有显著改善。结论 辣木治疗可减轻Wistar大鼠的MS。
