Watanabe Shihori, Okoshi Hiyori, Yamabe Shizuko, Shimada Masako
Graduate School of Nutritional Science, Sagami Women's University, 2-1-1 Bunkyo, Minami-ku, Sagamihara, Kanagawa 252-0383, Japan.
Department of Nutritional Science, Sagami Women's University, 2-1-1 Bunkyo, Minami-ku, Sagamihara, Kanagawa 252-0383, Japan.
Molecules. 2021 Jun 9;26(12):3513. doi: 10.3390/molecules26123513.
Plant-derived phytochemicals have been interested in as nutraceuticals for preventing the onset and progress of diabetes mellitus and its serious complications in recent years. Lam. is used in vegetables and in herbal medicine for its health-promoting properties against various diseases including diabetes mellitus. This study aimed to examine an effect of on diabetic hyperglycemia and dyslipidemia by meta-analyzing the current evidence of diabetic rodent models. Peer-reviewed studies written in English from two databases, PubMed and Embase, were searched to 30 April 2021. Studies reporting blood glucose or lipid levels in diabetic rodents with and without receiving extracts of were included. Forty-four studies enrolling 349 diabetic rodents treated with extracts of and 350 diabetic controls reported blood glucose levels. The pooled effect size was -3.92 (95% CI: -4.65 to -3.19) with a substantial heterogeneity. This effect was likely to be, at least in part, modified by the type of diabetic models. Moreover, diabetic hypertriglyceridemia and hypercholesterolemia were also significantly improved in diabetic rodent models treated with .
近年来，植物源植物化学物质作为营养保健品，在预防糖尿病及其严重并发症的发生和发展方面受到关注。Lam.因其对包括糖尿病在内的各种疾病具有促进健康的特性，被用于蔬菜和草药中。本研究旨在通过对糖尿病啮齿动物模型的现有证据进行荟萃分析，探讨其对糖尿病高血糖和血脂异常的影响。检索了截至2021年4月30日来自PubMed和Embase这两个数据库的英文同行评审研究。纳入了报告接受和未接受提取物治疗的糖尿病啮齿动物血糖或血脂水平的研究。44项研究共纳入349只接受提取物治疗的糖尿病啮齿动物和350只糖尿病对照，报告了血糖水平。合并效应量为-3.92（95%CI：-4.65至-3.19），存在显著异质性。这种效应可能至少部分受到糖尿病模型类型的影响。此外，在接受提取物治疗的糖尿病啮齿动物模型中，糖尿病性高甘油三酯血症和高胆固醇血症也得到了显著改善。
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