青少年肥胖、炎症与脂溶性维生素

Adiposity, inflammation and fat-soluble vitamins in adolescents.

机构信息

Universidade Federal de Pernambuco (UFPE), Departamento de Nutrição, Recife, PE, Brazil.

出版信息

J Pediatr (Rio J). 2019 Sep-Oct;95(5):575-583. doi: 10.1016/j.jped.2018.05.008. Epub 2018 Jun 29.

DOI:10.1016/j.jped.2018.05.008

PMID:29963989

Abstract

OBJECTIVE

Evaluate the association between inflammatory process, adiposity, and vitamins A, D, and E in adolescents, according to gender.

METHODS

Cross-sectional study with adolescents aged 12-19 years old of both genders attending public schools in Recife. A questionnaire was used to collect data on socioeconomic level, lifestyle, and food intake of adolescents. Then, an anthropometric evaluation and a blood sampling were performed to analyze serum concentrations of α-1-acid glycoprotein, retinol, β-carotene, α-tocopherol, and 25-hydroxy-vitamin D.

RESULTS

The levels of α-1-acid glycoprotein were higher for abdominal obesity in both genders. Male adolescents with insufficient serum α-tocopherol levels had low levels of α-1-acid glycoprotein (p=0.03) and an increased risk of 25-hydroxy-vitamin D and β-carotene deficiency in relation to total and abdominal fat; female adolescents had an increased risk of insufficient β-carotene with abdominal obesity (PR: 1.33; 95% CI: 1.2-1.5).

CONCLUSION

Abdominal adiposity implies a higher risk of inflammation and causes different changes to the levels of fat-soluble vitamins according to gender.

摘要

目的

根据性别评估炎症过程、肥胖与维生素 A、D 和 E 之间的关系。

方法

这是一项横断面研究，对象为来自累西腓公立学校的 12-19 岁的青少年。使用问卷调查收集青少年的社会经济水平、生活方式和饮食摄入数据。然后，进行人体测量评估和血液采样，以分析血清 α-1-酸性糖蛋白、视黄醇、β-胡萝卜素、α-生育酚和 25-羟基维生素 D 的浓度。

结果

在两性中，腹部肥胖者的 α-1-酸性糖蛋白水平更高。血清 α-生育酚水平不足的男性青少年，其 α-1-酸性糖蛋白水平较低（p=0.03），并且与总脂肪和腹部脂肪相关的 25-羟基维生素 D 和 β-胡萝卜素不足的风险增加；腹部肥胖的女性青少年β-胡萝卜素不足的风险增加（PR：1.33；95%CI：1.2-1.5）。