Çalan Mehmet, Alan Murat, Alarslan Pınar, Ünal Kocabaş Gökçen, Bozkaya Giray, Acara Ahmet Çağdaş, Aslanipour Behnaz, Fenercioğlu Özge, Işıl Ahmet Murat, Güler Aslı
Clinic of Internal Medicine, Division of Endocrinology and Metabolism, University of Health Sciences, İzmir Bozyaka Training and Research Hospital, İzmir, Turkey
Clinic of Obstetrics and Gynecology, University of Health Sciences, İzmir Tepecik Training and Research Hospital, İzmir, Turkey
J Turk Ger Gynecol Assoc. 2019 May 28;20(2):89-96. doi: 10.4274/jtgga.galenos.2018.2018.0027. Epub 2018 Jul 2.
C1q/tumor necrosis factor-related protein-5 (CTRP5) is a novel peptide hormone involved in the metabolism of energy regulation. Polycystic ovary syndrome (PCOS), which is a reproductive and metabolic disorder, is associated with insulin resistance. The aim of the current study was to compare circulating levels of CTRP5 in women with and without PCOS and to investigate possible associations between CTRP5 and metabolic-hormonal parameters.
The present cross-sectional study contained 80 women with PCOS and 80 age and body mass index-matched women without PCOS. Circulating levels of CTRP5 were calculated using an enzyme-linked immunosorbent assay. We also measured hormonal and metabolic parameters.
Patients with PCOS had lower levels of circulating CTRP5 compared with women without PCOS (6.90±2.64 vs 11.73±3.66 ng/mL, p<0.001). CTRP5 was negatively correlated with insulin resistance, free-androgen index, and body mass index in both the PCOS and control groups. Moreover, patients with PCOS who had insulin resistance showed lower circulating CTRP5 levels compared with those without insulin resistance. In both the control and PCOS groups, overweight subjects had lower circulating levels of CTRP5 compared with participants of normal weight. Logistic regression analyses indicated that subjects in the lowest tertile for CTRP5 level had higher risk for PCOS compared with those in the highest tertile of CTRP5.
Decreased circulating levels of CTRP5 were associated with higher risk of PCOS, as well as having metabolic disturbance among women with PCOS.
C1q/肿瘤坏死因子相关蛋白5（CTRP5）是一种参与能量调节代谢的新型肽类激素。多囊卵巢综合征（PCOS）是一种生殖和代谢紊乱疾病，与胰岛素抵抗有关。本研究的目的是比较患有和未患有PCOS的女性中CTRP5的循环水平，并研究CTRP5与代谢激素参数之间可能存在的关联。
本横断面研究纳入了80例PCOS女性患者以及80例年龄和体重指数相匹配的非PCOS女性。采用酶联免疫吸附测定法计算CTRP5的循环水平。我们还测量了激素和代谢参数。
与非PCOS女性相比，PCOS患者的CTRP5循环水平较低（6.90±2.64 vs 11.73±3.66 ng/mL，p<0.001）。在PCOS组和对照组中，CTRP5与胰岛素抵抗、游离雄激素指数和体重指数均呈负相关。此外，有胰岛素抵抗的PCOS患者的CTRP5循环水平低于无胰岛素抵抗的患者。在对照组和PCOS组中，超重受试者的CTRP5循环水平均低于正常体重参与者。逻辑回归分析表明，与CTRP5水平最高三分位数的受试者相比，CTRP5水平最低三分位数的受试者患PCOS的风险更高。
CTRP5循环水平降低与PCOS风险增加以及PCOS女性的代谢紊乱有关。
