Jiang Feiyu, Yang Min, Zhao Xili, Liu Rui, Yang Gangyi, Liu Dongfang, Liu Hua, Zheng Hongting, Zhu Zhiming, Li Ling
Key Laboratory of Diagnostic Medicine (Ministry of Education) and Department of Clinical Biochemistry, College of Laboratory Medicine, Chongqing Medical University, 400016, China.
Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Int J Endocrinol. 2018 Nov 22;2018:7201473. doi: 10.1155/2018/7201473. eCollection 2018.
C1q/TNF-related protein5 (CTRP5) is a member of the C1q/tumor necrosis factor - (TNF--) related protein family and has been reported to be associated with the regulation of glucose and lipid metabolism. However, the clinical association between CTRP5 and metabolic syndrome (MetS) has not been reported. The aim of the current study is to investigate the association between CTRP5 and MetS by a cross-sectional study.
We performed a cross-sectional study in a Chinese population including 89 controls and 88 MetS individuals. Serum CTRP5 concentrations were determined by ELISA. The relationship between circulating CTRP5 and MetS and insulin resistance (IR) was assessed by Spearman's correlation and multiple stepwise regression analysis.
Circulating CTRP5 concentrations were markedly decreased in MetS individuals relative to normal adults. Overweight/obese individuals (BMI ≥ 25 kg/m) showed a lower serum CTRP5 level than lean subjects (BMI < 25 kg/m) in the study population (124.1 (99.12-147.37) vs. 103.9 (79.15-124.25) g/L; < 0.01). Circulating CTRP5 was found to be correlated negatively with BMI, FAT%, FBG, WHR, SBP, HbA1c, TG, 2-hour blood glucose after glucose overload (2-hOGTT), FIns, and HOMA-IR and positively with HDL-C ( < 0.05 or < 0.01). Binary logistic regression revealed that serum CTRP5 levels were associated with MetS. In addition, serum CTRP5 levels gradually decreased with the increase in MetS components.
Circulating CTRP5 is relative to the elevated risk of MetS in humans and may be in part through the effect of insulin resistance. This trial is registered with ChiCTR-OCS-13003185.
C1q/TNF相关蛋白5（CTRP5）是C1q/肿瘤坏死因子-（TNF-）相关蛋白家族的成员，据报道与葡萄糖和脂质代谢的调节有关。然而，CTRP5与代谢综合征（MetS）之间的临床关联尚未见报道。本研究旨在通过横断面研究探讨CTRP5与MetS之间的关联。
我们对一个中国人群进行了横断面研究，包括89名对照者和88名MetS患者。采用酶联免疫吸附测定法（ELISA）测定血清CTRP5浓度。通过Spearman相关性分析和多元逐步回归分析评估循环CTRP5与MetS及胰岛素抵抗（IR）之间的关系。
与正常成年人相比，MetS患者的循环CTRP5浓度显著降低。在研究人群中，超重/肥胖个体（BMI≥25kg/m）的血清CTRP5水平低于瘦个体（BMI<25kg/m）（124.1（99.12 - 147.37）对103.9（79.15 - 124.25）μg/L；P<0.01）。发现循环CTRP5与BMI、脂肪百分比、空腹血糖（FBG）、腰臀比（WHR）、收缩压（SBP）、糖化血红蛋白（HbA1c）、甘油三酯（TG）、葡萄糖负荷后2小时血糖（2-hOGTT）、空腹胰岛素（FIns）和稳态模型评估的胰岛素抵抗（HOMA-IR）呈负相关，与高密度脂蛋白胆固醇（HDL-C）呈正相关（P<0.05或P<0.01）。二元逻辑回归显示血清CTRP5水平与MetS有关。此外，血清CTRP5水平随着MetS组分数量的增加而逐渐降低。
循环CTRP5与人类患MetS的风险升高相关，可能部分是通过胰岛素抵抗的作用。本试验在中国临床试验注册中心注册号为ChiCTR-OCS-13003185。
