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本文引用的文献

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Genomic context of resistance genes within a French clinical MDR Proteus mirabilis: identification of the novel genomic resistance island GIPmi1.法国临床多重耐药奇异变形杆菌中耐药基因的基因组背景：新型基因组耐药岛 GIPmi1 的鉴定。
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Redefinition and Unification of the SXT/R391 Family of Integrative and Conjugative Elements.重新定义和统一 SXT/R391 家族的整合和共轭元件。
Appl Environ Microbiol. 2018 Jun 18;84(13). doi: 10.1128/AEM.00485-18. Print 2018 Jul 1.
3
Identification and characterization of new members of the SXT/R391 family of integrative and conjugative elements (ICEs) in Proteus mirabilis.鉴定和描述奇异变形杆菌 SXT/R391 家族整合子和可移动元件（ICEs）的新成员。
Int J Antimicrob Agents. 2017 Aug;50(2):242-246. doi: 10.1016/j.ijantimicag.2017.01.045. Epub 2017 Jun 8.
4
SXT/R391 integrative and conjugative elements in Proteus species reveal abundant genetic diversity and multidrug resistance.SXT/R391 整合子/转座子在变形杆菌属中揭示了丰富的遗传多样性和多重耐药性。
Sci Rep. 2016 Nov 28;6:37372. doi: 10.1038/srep37372.
5
Genome-based phylogeny and taxonomy of the 'Enterobacteriales': proposal for Enterobacterales ord. nov. divided into the families Enterobacteriaceae, Erwiniaceae fam. nov., Pectobacteriaceae fam. nov., Yersiniaceae fam. nov., Hafniaceae fam. nov., Morganellaceae fam. nov., and Budviciaceae fam. nov.基于基因组的“肠杆菌目”系统发育与分类学：肠杆菌目新目提案，该目分为肠杆菌科、新科欧文氏菌科、新科果胶杆菌科、新科耶尔森氏菌科、新科哈夫尼菌科、新科摩根氏菌科和新科布德维氏菌科。
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IS26-Mediated Formation of Transposons Carrying Antibiotic Resistance Genes.IS26介导的携带抗生素抗性基因的转座子的形成。
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7
Characterization of SXT/R391 Integrative and Conjugative Elements in Proteus mirabilis Isolates from Food-Producing Animals in China.中国产肉用动物奇异变形杆菌分离株中SXT/R391整合与接合元件的特征分析
Antimicrob Agents Chemother. 2016 Jan 11;60(3):1935-8. doi: 10.1128/AAC.02852-15.
8
The extended regulatory networks of SXT/R391 integrative and conjugative elements and IncA/C conjugative plasmids.SXT/R391整合与接合元件以及IncA/C接合质粒的扩展调控网络
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9
Replication and Active Partition of Integrative and Conjugative Elements (ICEs) of the SXT/R391 Family: The Line between ICEs and Conjugative Plasmids Is Getting Thinner.SXT/R391家族整合性接合元件（ICEs）的复制与活性分区：ICEs与接合质粒之间的界限正变得越来越模糊。
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10
Transfer activation of SXT/R391 integrative and conjugative elements: unraveling the SetCD regulon.SXT/R391整合与接合元件的转移激活：解析SetCD调控子
Nucleic Acids Res. 2015 Feb 27;43(4):2045-56. doi: 10.1093/nar/gkv071. Epub 2015 Feb 6.

奇异变形杆菌中新的 SXT/R391 整合子-转座子元件携带 、 、 和 。

Characterization of a Novel SXT/R391 Integrative and Conjugative Element Carrying , , , and in Proteus mirabilis.

机构信息

Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, People's Republic of China.

Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Chengdu, People's Republic of China.

出版信息

Antimicrob Agents Chemother. 2018 Aug 27;62(9). doi: 10.1128/AAC.00849-18. Print 2018 Sep.

DOI:10.1128/AAC.00849-18
PMID:29967018
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6125529/
Abstract

A novel 139,487-bp SXT/R391 integrative and conjugative element, ICEChnBCP11, was characterized in of swine origin in China. ICEChnBCP11 harbors 20 different antimicrobial resistance genes, including the clinically important rRNA methyltransferase gene , the extended-spectrum β-lactamase gene , fosfomycin resistance gene , and fluoroquinolone resistance gene An IS-mediated composite transposon containing various resistance genes and 10 copies of IS is inserted in hot spot 4. ICEChnBCP11 was successfully transferred to .

摘要

一种新型的 139487 碱基对的 SXT/R391 整合子-转座子元件 ICEChnBCP11，在中国的猪源中被发现。ICEChnBCP11 携带 20 种不同的抗生素耐药基因，包括临床上重要的 rRNA 甲基化酶基因 、超广谱β-内酰胺酶基因 、磷霉素耐药基因 以及氟喹诺酮耐药基因 。一个由 IS 介导的复合转座子，其中包含各种耐药基因和 10 个拷贝的 IS，插入在热点 4 中。ICEChnBCP11 成功地被转移到 中。