奇异变形杆菌中新的 SXT/R391 整合子-转座子元件携带 、 、 和 。
Characterization of a Novel SXT/R391 Integrative and Conjugative Element Carrying , , , and in Proteus mirabilis.
机构信息
Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, People's Republic of China.
Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Chengdu, People's Republic of China.
出版信息
Antimicrob Agents Chemother. 2018 Aug 27;62(9). doi: 10.1128/AAC.00849-18. Print 2018 Sep.
Abstract
A novel 139,487-bp SXT/R391 integrative and conjugative element, ICEChnBCP11, was characterized in of swine origin in China. ICEChnBCP11 harbors 20 different antimicrobial resistance genes, including the clinically important rRNA methyltransferase gene , the extended-spectrum β-lactamase gene , fosfomycin resistance gene , and fluoroquinolone resistance gene An IS-mediated composite transposon containing various resistance genes and 10 copies of IS is inserted in hot spot 4. ICEChnBCP11 was successfully transferred to .
摘要
一种新型的 139487 碱基对的 SXT/R391 整合子-转座子元件 ICEChnBCP11，在中国的猪源中被发现。ICEChnBCP11 携带 20 种不同的抗生素耐药基因，包括临床上重要的 rRNA 甲基化酶基因 、超广谱β-内酰胺酶基因 、磷霉素耐药基因 以及氟喹诺酮耐药基因 。一个由 IS 介导的复合转座子，其中包含各种耐药基因和 10 个拷贝的 IS，插入在热点 4 中。ICEChnBCP11 成功地被转移到 中。
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