Drayer B P, Rosenbaum A E
Neuroradiology Division, University of Pittsburgh School of Medicine, Presbyterian-University Hospital, Pennsylvania 15261.
Acta Radiol Suppl. 1977;355:280-93.
The normal cerebrospinal fluid flow as monitored by serial CT cisternography with metrizamide (Amipaque) is described in 25 individuals. Preliminary gross autoradiography using 131I-labelled metrizamide concur with these CT cisternographic findings indicating that intrathecally introduced metrizamide penetrates the brain substance. Adverse reactions are most prominent during the periods of maximum brain penetration and include headache, nausea, perceptual aberrations, and EEG alterations. The value and diagnostic applications of cerebral and cerebellar penetration of metrizamide are also discussed.
本文描述了25例通过使用甲泛葡胺（阿米培克）进行连续脑池CT造影监测的正常脑脊液流动情况。使用131I标记的甲泛葡胺进行的初步大体放射自显影结果与这些脑池CT造影结果一致，表明鞘内注入的甲泛葡胺可穿透脑实质。不良反应在脑穿透最明显的时期最为突出，包括头痛、恶心、感知异常和脑电图改变。文中还讨论了甲泛葡胺对脑和小脑的穿透作用的价值及诊断应用。
