Department of Pharmacognosy and Phytochemistry, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland.
Department of Pharmacology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland.
Oxid Med Cell Longev. 2018 Jun 4;2018:9274246. doi: 10.1155/2018/9274246. eCollection 2018.
Sinapic acid is a natural phenolic acid found in fruits, vegetables, and cereals, exerting numerous pharmacological effects. The aim of the study was to investigate the influence of sinapic acid on biochemical parameters related to glucose and lipid metabolism, as well as markers of antioxidant abilities and parameters of oxidative damage in the blood serum in estrogen-deficient rats. The study was performed on 3-month-old female Wistar rats, divided into 5 groups, including sham-operated control rats, ovariectomized control rats, and ovariectomized rats administered orally with estradiol (0.2 mg/kg) or sinapic acid (5 and 25 mg/kg) for 28 days. The levels of estradiol, progesterone, interleukin 18, insulin, glucose, fructosamine, lipids, and enzymatic and nonenzymatic antioxidants (superoxide dismutase, catalase, and glutathione); total antioxidant capacity; and oxidative damage parameters (thiobarbituric acid-reactive substances, protein carbonyl groups, and advanced oxidation protein products) were determined in the serum. Estradiol counteracted the carbohydrate and cholesterol metabolism disorders induced by estrogen deficiency. Sinapic acid increased the serum estradiol concentration; decreased insulin resistance and the triglyceride and total cholesterol concentrations; and favorably affected the parameters of antioxidant abilities (reduced glutathione, superoxide dismutase) and oxidative damage (advanced oxidation protein products).
芥子酸是一种天然酚酸，存在于水果、蔬菜和谷物中，具有多种药理作用。本研究旨在探讨芥子酸对去势雌鼠血糖和脂代谢相关生化参数、抗氧化能力标志物以及血清氧化损伤参数的影响。研究采用 3 月龄雌性 Wistar 大鼠，分为 5 组，包括假手术对照组、去势对照组、去势雌鼠给予 0.2mg/kg 雌二醇和 5、25mg/kg 芥子酸口服 28 天。测定血清中雌二醇、孕酮、白细胞介素 18、胰岛素、血糖、果糖胺、脂质、酶和非酶抗氧化剂（超氧化物歧化酶、过氧化氢酶和谷胱甘肽）；总抗氧化能力；以及氧化损伤参数（硫代巴比妥酸反应物质、蛋白羰基和高级氧化蛋白产物）。雌二醇拮抗了雌激素缺乏引起的碳水化合物和胆固醇代谢紊乱。芥子酸增加了血清雌二醇浓度；降低了胰岛素抵抗和甘油三酯及总胆固醇浓度；并对抗氧化能力参数（还原型谷胱甘肽、超氧化物歧化酶）和氧化损伤参数（高级氧化蛋白产物）产生有利影响。
