Jimenez Antonio R, Rivera Rolon Maria Del Mar, Eyzaguirre Eduardo, Clement Cecilia
Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA.
Case Rep Pathol. 2018 Jun 4;2018:2109279. doi: 10.1155/2018/2109279. eCollection 2018.
Renal cell carcinoma is the third most common urogenital cancer. In some patients, it can metastasize to distant organs. Metastasis to the vagina is extremely rare.
A 54-year-old female with unremarkable history presented to the clinic with a chief complaint of vaginal bleeding. Further examination identified a pedunculated mass on the vaginal wall. Histologic examination revealed a metastatic clear cell renal cell carcinoma. Radiological studies then revealed a left renal mass and bilateral adrenal masses. The patient underwent a nephrectomy, adrenalectomy, and resection of the vaginal mass. The mass in the vagina has since recurred.
We report the first known case of vaginal metastasis as initial presentation of a renal cell carcinoma with rhabdoid features. Postmenopausal women with renal cell carcinoma who present with vaginal bleeding should undergo a thorough inspection of the vaginal wall for the potential of metastatic neoplasms.
肾细胞癌是第三常见的泌尿生殖系统癌症。在一些患者中，它可转移至远处器官。转移至阴道极为罕见。
一名54岁女性，既往史无特殊，因阴道出血为主诉前来就诊。进一步检查发现阴道壁有一个带蒂肿物。组织学检查显示为转移性透明细胞肾细胞癌。影像学检查随后发现左肾肿物及双侧肾上腺肿物。患者接受了肾切除术、肾上腺切除术及阴道肿物切除术。此后阴道肿物复发。
我们报告了首例以横纹肌样特征的肾细胞癌首发表现为阴道转移的病例。出现阴道出血的绝经后肾细胞癌女性患者应全面检查阴道壁，以排查转移性肿瘤的可能。
