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转移性肾细胞癌与意外肾上腺功能不全:一例报告及文献综述

Metastatic Renal Cell Carcinoma and Unforeseen Adrenal Insufficiency: A Case Report and Literature Review.

作者信息

Repp Matthew L, Alvarez Rodrigo A, Arevalo-Salazar Dory E, Kotagiri Rajesh

机构信息

Medical School, University of Arizona College of Medicine, Tucson, USA.

Internal Medicine, University of Arizona College of Medicine, Tucson, USA.

出版信息

Cureus. 2023 Feb 21;15(2):e35265. doi: 10.7759/cureus.35265. eCollection 2023 Feb.

DOI:10.7759/cureus.35265
PMID:36968872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10035604/
Abstract

Renal cell carcinoma (RCC) can metastasize to nearly every organ, yet rarely metastasizes to the adrenal glands despite their anatomical proximity. Adrenal metastases are typically incidental findings on medical imaging and are vastly clinically asymptomatic. The adrenal glands can maintain hormonal homeostasis if a tenth of total adrenal gland function is preserved. We present a patient with synchronous bilateral adrenal metastases from RCC with rapid and unexpected development of adrenal insufficiency (AI).

摘要

肾细胞癌(RCC)几乎可转移至每个器官,但尽管肾上腺与肾脏解剖位置相近,RCC很少转移至肾上腺。肾上腺转移瘤通常是在医学影像检查中偶然发现的,临床上大多无症状。如果保留肾上腺总功能的十分之一,肾上腺就能维持激素稳态。我们报告了一例肾细胞癌同步双侧肾上腺转移患者,该患者肾上腺功能不全(AI)迅速且意外地发展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10f7/10035604/8a58447ed71f/cureus-0015-00000035265-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10f7/10035604/6feb0148fb84/cureus-0015-00000035265-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10f7/10035604/8a58447ed71f/cureus-0015-00000035265-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10f7/10035604/6feb0148fb84/cureus-0015-00000035265-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10f7/10035604/8a58447ed71f/cureus-0015-00000035265-i02.jpg

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本文引用的文献

1
Bilateral adrenal metastasis of renal cell carcinoma 4 years after radical nephrectomy: A case report and review of literature.根治性肾切除术后 4 年双侧肾上腺转移的肾细胞癌:病例报告及文献复习。
Medicine (Baltimore). 2021 Aug 6;100(31):e26838. doi: 10.1097/MD.0000000000026838.
2
Adrenal insufficiency due to bilateral adrenal metastases - A systematic review and meta-analysis.双侧肾上腺转移所致肾上腺功能不全——一项系统评价与荟萃分析
Heliyon. 2019 May 29;5(5):e01783. doi: 10.1016/j.heliyon.2019.e01783. eCollection 2019 May.
3
Rare Case of Synchronous Cystic Duct Metastasis from Renal Cell Carcinoma.
肾细胞癌同步性胆囊管转移罕见病例
J Nippon Med Sch. 2019 Sep 3;86(4):242-247. doi: 10.1272/jnms.JNMS.2018_86-405. Epub 2019 Apr 26.
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Bilateral renal cell carcinoma with bilateral adrenal metastasis: a therapeutic challenge.双侧肾细胞癌伴双侧肾上腺转移:一项治疗挑战。
BMJ Case Rep. 2018 Dec 13;11(1):e227176. doi: 10.1136/bcr-2018-227176.
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Vaginal Bleeding as Initial Presentation of an Aggressive Renal Cell Carcinoma: A Case Report and Review of the Literature.阴道出血作为侵袭性肾细胞癌的首发表现:一例病例报告及文献复习
Case Rep Pathol. 2018 Jun 4;2018:2109279. doi: 10.1155/2018/2109279. eCollection 2018.
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Simultaneous Bilateral Laparoscopic Adrenalectomy for Adrenal Metastases of Renal Cell Carcinoma: A Case Report.同步双侧腹腔镜肾上腺切除术治疗肾细胞癌肾上腺转移:1例报告
J Endourol Case Rep. 2017 Sep 1;3(1):142-145. doi: 10.1089/cren.2017.0062. eCollection 2017.
7
Metastatic renal cell carcinoma without evidence of a renal primary.转移性肾细胞癌,无肾原发灶证据。
Int Urol Nephrol. 2016 Jan;48(1):73-7. doi: 10.1007/s11255-015-1145-3. Epub 2015 Nov 2.
8
Bilateral synchronous adrenal metastases of renal cell carcinoma: A case report and review of the literature.肾细胞癌双侧同步肾上腺转移:一例报告并文献复习
Oncol Lett. 2015 Apr;9(4):1897-1901. doi: 10.3892/ol.2015.2915. Epub 2015 Jan 28.
9
Bilateral metachronous adrenal metastases of operated renal cell carcinoma.手术切除的肾细胞癌双侧异时性肾上腺转移
Urologia. 2015 Apr-Jun;82(2):114-7. doi: 10.5301/uro.5000094. Epub 2014 Nov 25.
10
A unique presentation of an undiagnosed renal cell carcinoma.一例未确诊肾细胞癌的独特表现。
Case Rep Urol. 2014;2014:840163. doi: 10.1155/2014/840163. Epub 2014 Nov 6.