Adnan Mohd, Alshammari Eyad, Patel Mitesh, Amir Ashraf Syed, Khan Saif, Hadi Sibte
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Hail, Hail, Saudi Arabia.
Department of Clinical Nutrition, College of Applied Medical Sciences, University of Hail, Hail, Saudi Arabia.
PeerJ. 2018 Jun 27;6:e5049. doi: 10.7717/peerj.5049. eCollection 2018.
Natural products from the unique environments of sea water and oceans represent a largely unfamiliar source for isolation of new microbes, which are potent producers of secondary bioactive metabolites. These unique life-forms from the marine ecosphere have served as an important source of drugs since ancient times and still offer a valuable resource for novel findings by providing remedial treatments. Therefore, it can be expected that many naturally bioactive marine microbial compounds with novel structures and bioactivities against those from terrestrial environments may be found among marine metabolites. Biofilms in aquatic environment possess serious problems to naval forces and oceanic industries around the globe. Current anti-biofilm or anti-biofouling technology is based on the use of toxic substances that can be harmful to their surrounding natural locales. Comprehensive research has been done to examine the bioactive potential of marine microbes. Results are remarkably varied and dynamic, but there is an urgent need for bioactive compounds with environmentally friendly or "green" chemical activities. Marine microbes have the potential as upcoming and promising source of non-toxic compounds with sustainable anti-biofouling/anti-biofilm properties as they can produce substances that can inhibit not only the chemical components required for biofilm production but also the attachment, microorganism growth, and/or cell-cell communication.
来自海水和海洋独特环境的天然产物是一个相对陌生的新微生物分离来源，这些微生物是次生生物活性代谢物的有效生产者。自古以来，这些来自海洋生态圈的独特生命形式一直是药物的重要来源，并且通过提供治疗方法，仍然为新发现提供了宝贵资源。因此，可以预期，在海洋代谢产物中可能会发现许多具有新颖结构和生物活性、与陆地环境中的化合物不同的天然生物活性海洋微生物化合物。水生环境中的生物膜给全球海军部队和海洋产业带来了严重问题。当前的抗生物膜或抗生物污损技术基于使用可能对其周围自然区域有害的有毒物质。人们已经对海洋微生物的生物活性潜力进行了全面研究。结果差异很大且动态变化，但迫切需要具有环境友好型或“绿色”化学活性的生物活性化合物。海洋微生物有潜力成为即将出现且有前景的无毒化合物来源，具有可持续的抗生物污损/抗生物膜特性，因为它们能够产生不仅可以抑制生物膜形成所需化学成分，还能抑制附着、微生物生长和/或细胞间通讯的物质。
