University of Kristianstad, Elmetorpsvägen 15, 291 88, Kristianstad, Sweden.
Department of Periodontics, University of Washington, Seattle, WA, USA.
Clin Oral Investig. 2019 Mar;23(3):1171-1179. doi: 10.1007/s00784-018-2533-8. Epub 2018 Jul 2.
To assess if carotid calcifications detected in panoramic radiographs are associated with future events of stroke, and/or ischemic heart diseases over 10-13 years in individuals between 60 and 96 years.
Baseline (2001-2004) panoramic radiographs were assessed for evidence of carotid calcifications from individuals with no previous history of stroke and/or ischemic heart diseases. A radiopaque nodular mass adjacent to the cervical vertebrae, at or below the intervertebral space C3-C4, was interpreted as carotid calcification. Annual medical records were searched for ICD 10 codes through 2014.
Signs of carotid calcification was demonstrated in 238/635 (37.5%) of the study individuals. Signs of carotid calcification was associated with future stroke and/or ischemic heart diseases (χ = 9.1, OR 1.6, 95% CI 1.2, 2.2, p < 0.002). In individuals 60-72 years, a significant association between radiographic signs of carotid calcification and stroke and/or ischemic heart diseases (χ = 12.4, OR 2.4, 95% CI 1.5, 4.0, p < 0.000) (adjusted for high blood pressure, diabetes type 2, BMI; OR 1.9, 95% CI 1.1, 3.5, p = 0.03). Individuals (60-72 years) with radiographic evidence of carotid calcifications had a mean cumulative stroke and/or ischemic heart diseases survival time of 12.1 years compared to those without such evidence (13.0 years) (log rank Mantel-Cox χ = 10.7, p = 0.001).
Evidence of carotid calcifications in panoramic radiographs is associated with an event of stroke and/or ischemic heart diseases in 60-96-year-old individuals.
Radiographic evidence of carotid calcifications is associated with stroke and/or ischemic heart diseases. Patients with signs of carotid calcifications should therefore be referred for medical examination.
评估全景放射片中检测到的颈动脉钙化是否与 60-96 岁人群中 10-13 年内未来发生中风和/或缺血性心脏病事件有关。
对无中风和/或缺血性心脏病既往病史的个体的基线（2001-2004 年）全景放射片进行评估，以发现颈动脉钙化的证据。与颈椎相邻、位于 C3-C4 椎间空间以下或与之相邻的放射状结节状肿块被解释为颈动脉钙化。通过 2014 年的 ICD 10 代码对每年的医疗记录进行了搜索。
研究个体中有 238/635（37.5%）表现出颈动脉钙化的迹象。颈动脉钙化的迹象与未来中风和/或缺血性心脏病有关（χ=9.1，OR 1.6，95%CI 1.2，2.2，p<0.002）。在 60-72 岁的个体中，放射学上有颈动脉钙化迹象与中风和/或缺血性心脏病之间存在显著关联（χ=12.4，OR 2.4，95%CI 1.5，4.0，p<0.000）（调整了高血压、2 型糖尿病、BMI；OR 1.9，95%CI 1.1，3.5，p=0.03）。有放射学证据表明存在颈动脉钙化的个体（60-72 岁）的中风和/或缺血性心脏病累积生存时间平均为 12.1 年，而无此类证据的个体为 13.0 年（对数秩 Mantel-Cox χ=10.7，p=0.001）。
全景放射片中颈动脉钙化的证据与 60-96 岁个体中风和/或缺血性心脏病事件有关。
颈动脉钙化的放射学证据与中风和/或缺血性心脏病有关。因此，有颈动脉钙化迹象的患者应接受医学检查。
