Green T R, Fellman J H, Eicher A L
FEBS Lett. 1985 Nov 11;192(1):33-6. doi: 10.1016/0014-5793(85)80037-5.
Myeloperoxidase (MPO) oxidizes sulfur-centered and benzoate hydroxyl radical scavengers through formation of HOCl. Sulfur-centered hydroxyl radical scavengers compete with benzoate as antioxidants of HOCl. We conclude from these observations that competition experiments between benzoate and sulfur-centered hydroxyl radical scavengers are not sufficiently specific to infer participation of hydroxyl radicals in oxidative reactions mediated by neutrophils because of the unique action of MPO in affecting oxidation of the test radical scavengers.
髓过氧化物酶（MPO）通过生成次氯酸氧化以硫为中心的和苯甲酸酯类羟基自由基清除剂。以硫为中心的羟基自由基清除剂作为次氯酸的抗氧化剂与苯甲酸酯竞争。我们从这些观察结果得出结论，由于MPO在影响测试自由基清除剂氧化方面的独特作用，苯甲酸酯和以硫为中心的羟基自由基清除剂之间的竞争实验不足以特异性地推断羟基自由基参与中性粒细胞介导的氧化反应。
