Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Development of Research and Technology Center, Deputy of Research and Technology, Ministry of Health and Medical Education, Tehran, Iran.
Eat Weight Disord. 2020 Feb;25(1):151-161. doi: 10.1007/s40519-018-0534-x. Epub 2018 Jul 3.
The association of Wrist Circumference (WrC) with cardio-metabolic risk factors is still contradictory. We aimed to systematically review the association of WrC with cardio-metabolic diseases among the general populations.
We systematically searched electronic databases such as PubMed/Medline, Web of Sciences, and Scopus without language restriction until March 2017. Observational studies that examined the association of WrC with any cardio-metabolic risk factors were included. Pooled association of WrC with metabolic syndrome (MetS) was estimated using a random-effect model, and heterogeneity among studies was assessed by I index and Q test.
A total of 14 papers including cohort study (n = 9), cross-sectional study (n = 4), and case-control study (n = 1) met the criteria and included. The eligible papers have been examined the association of WrC with any cardiovascular disorders (n = 8), metabolic syndrome (n = 4), insulin resistance (IR) (n = 5), diabetes mellitus (n = 2), impaired glucose tolerance (n = 1), cardio-metabolic risk factors (n = 2) and obesity/overweight (n = 1). In the whole population (both adults and pediatric population), high WrC increased the risk of MetS by 33% (Pooled OR = 1.33; 95% CI 1.20, 1.48; I = 60.2%, p = 0.04), while the pooled OR in adult populations was 1.27 (95% CI 1.15-1.41; I: 32.8%, p = 0.21). Qualitative synthesis showed that associations of WrC with other cardio-metabolic risk factors are conflicting.
High WrC increased the risk of MetS and other cardio-metabolic risk factors. However, due to limited studies, particularly in children, results should be declared with great caution. Further cohort studies are needed to clarify whether WrC is a suitable anthropometric index to predict cardio-metabolic disorders in adult and children populations in different societies.
Level 1, systematic review and meta-analysis.
腕围（WrC）与心血管代谢危险因素的相关性仍然存在争议。本研究旨在系统地综述一般人群中 WrC 与心血管代谢疾病的相关性。
我们系统地检索了电子数据库，如 PubMed/Medline、Web of Sciences 和 Scopus，没有语言限制，检索时间截至 2017 年 3 月。纳入了观察性研究，这些研究检查了 WrC 与任何心血管代谢危险因素的相关性。使用随机效应模型估计 WrC 与代谢综合征（MetS）的汇总相关性，并通过 I 指数和 Q 检验评估研究间的异质性。
共有 14 篇论文符合标准，包括队列研究（n=9）、横断面研究（n=4）和病例对照研究（n=1）。这些符合条件的论文研究了 WrC 与任何心血管疾病（n=8）、代谢综合征（n=4）、胰岛素抵抗（IR）（n=5）、糖尿病（n=2）、葡萄糖耐量受损（n=1）、心血管代谢危险因素（n=2）和肥胖/超重（n=1）的相关性。在整个人群（包括成人和儿科人群）中，高 WrC 使 MetS 的风险增加 33%（汇总 OR=1.33；95%CI 1.20，1.48；I=60.2%，p=0.04），而在成人人群中的汇总 OR 为 1.27（95%CI 1.15-1.41；I：32.8%，p=0.21）。定性综合表明，WrC 与其他心血管代谢危险因素的相关性存在争议。
高 WrC 增加了 MetS 和其他心血管代谢危险因素的风险。然而，由于研究数量有限，特别是在儿童中，结果应谨慎解释。需要进一步的队列研究来阐明 WrC 是否是预测不同社会成人和儿童人群心血管代谢疾病的合适人体测量指标。
1 级，系统评价和荟萃分析。
