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儿童特发性和综合征性肥胖的心血管影响:最新进展。

Cardiovascular Implications in Idiopathic and Syndromic Obesity in Childhood: An Update.

机构信息

Metabolic Disorders and Diabetes Unit, "Giovanni XXIII" Children Hospital, AOU Policlinico di Bari, Bari, Italy.

"B. Trambusti" Pediatric Unit, "Giovanni XXIII" Children Hospital, AOU Policlinico di Bari, Bari, Italy.

出版信息

Front Endocrinol (Lausanne). 2020 Jun 9;11:330. doi: 10.3389/fendo.2020.00330. eCollection 2020.

Abstract

Childhood obesity is a modern worldwide epidemic with significant burden for health. It is a chronic metabolic disorder associated with multiple cardiovascular risk factors such as dyslipidemia, hypertension, stroke, and insulin resistance. Many obese adolescents remain obese into adulthood, with increased morbidity and mortality. As childhood obesity is a risk factor for adult obesity, the childhood obesity-related disorders account for an increased risk of cardiovascular consequences in adults, in addition to the effects already exerted by the fat mass in adulthood. Several papers have already described the cardiovascular implications of idiopathic obesity, while few data are available about syndromic obesity, due to the small sample size, not homogeneous phenotypes, and younger age at death. The aim of this mini-review is to give a comprehensive overview on knowledge about cardiovascular implications of idiopathic and syndromic obesity to allow the reader a quick comparison between them. The similarities and differences will be highlighted.

摘要

儿童肥胖是一种现代全球流行疾病,对健康造成重大负担。它是一种与多种心血管危险因素相关的慢性代谢紊乱,如血脂异常、高血压、中风和胰岛素抵抗。许多肥胖的青少年在成年后仍然肥胖,发病率和死亡率增加。由于儿童肥胖是成年肥胖的一个危险因素,因此儿童肥胖相关疾病会增加成年人患心血管疾病的风险,此外,脂肪量在成年期已经产生了影响。已经有几篇论文描述了特发性肥胖的心血管影响,而由于样本量小、表型不均匀和死亡年龄较小,关于综合征性肥胖的相关数据很少。本综述的目的是全面概述特发性和综合征性肥胖的心血管影响,以便读者能够快速比较它们。将突出它们的异同点。

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