Xie Lianguang, Chen Yang, Tan Aihua, Gao Yong, Yang Xiaobo, Mo Zengnan, Zhang Haiying
School of Public Health, Guangxi Medical University, Nanning, China.
Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, China.
Low Urin Tract Symptoms. 2019 Apr;11(2):O135-O140. doi: 10.1111/luts.12231. Epub 2018 Jul 11.
The aim of this study was to explore the association between central obesity and lower urinary tract symptoms (LUTS) among men in southern China, and test the hypothesis that central obesity measured by the waist-to-hip ratio (WHR) is a predictor of the severity of LUTS.
In all, 4303 men from the Fangchenggang Area Male Healthy and Examination Survey (FAMHES) were included in this study. LUTS were assessed by the International Prostate Symptom Score (IPSS), whereas central obesity was evaluated by the WHR. The association between WHR and LUTS was tested using logistic and Cox regression analyses.
After screening, 2917 participants were in the study. Univariate analysis indicated significant differences in WHR in the presence of LUTS (P = .012). After stratification by age, logistic regression indicated that LUTS were more frequent in 60-year-old men with a higher WHR (odds ratio [OR] 2.89, 95% confidence interval [CI] 1.21-6.89) compared with participants <40 years old. Cox regression analysis after pairing of 252 LUTS cases and 252 control subjects from the 2917 eligible participants according to age (±5 years), indicated that central obesity (WHR ≥0.9) may be significantly associated with moderate or severe LUTS (OR 1.95, 95% CI 1.16-3.26). The associations between central obesity and straining (OR 2.44, 95% CI 1.40-4.24) and weak stream (OR 2.37, 95% CI 1.27-4.45) were significant after multivariate adjustment.
Males with central obesity are at increased risk of LUTS, and increased WHR is associated with worsened straining and weak stream. Further investigations are needed to confirm these associations.
本研究旨在探讨中国南方男性中心性肥胖与下尿路症状（LUTS）之间的关联，并检验以腰臀比（WHR）衡量的中心性肥胖是LUTS严重程度预测指标这一假设。
本研究纳入了来自防城港地区男性健康与检查调查（FAMHES）的4303名男性。LUTS通过国际前列腺症状评分（IPSS）进行评估，而中心性肥胖通过WHR进行评估。使用逻辑回归和Cox回归分析来检验WHR与LUTS之间的关联。
筛选后，2917名参与者进入研究。单因素分析表明，存在LUTS时WHR有显著差异（P = 0.012）。按年龄分层后，逻辑回归表明，与40岁以下参与者相比，60岁且WHR较高的男性LUTS更为常见（比值比[OR] 2.89，95%置信区间[CI] 1.21 - 6.89）。根据年龄（±5岁）从2917名符合条件的参与者中配对252例LUTS病例和252例对照受试者后进行的Cox回归分析表明，中心性肥胖（WHR≥0.9）可能与中度或重度LUTS显著相关（OR 1.95，95% CI 1.16 - 3.26）。多因素调整后，中心性肥胖与排尿费力（OR 2.44，95% CI 1.40 - 4.24）和尿流减弱（OR 2.37，95% CI 1.27 - 4.45）之间的关联显著。
中心性肥胖男性患LUTS的风险增加，且WHR升高与排尿费力和尿流减弱加重相关。需要进一步研究来证实这些关联。
