Modeling the Hidden Pathways of IKs Channel Activation.
作者信息
Fedida David
机构信息
Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.
出版信息
Biophys J. 2018 Jul 3;115(1):1-2. doi: 10.1016/j.bpj.2018.05.020.
Abstract
摘要
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Channels (Austin). 2018 Jan 1;12(1):89-99. doi: 10.1080/19336950.2018.1441649.
2
Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening.失活 KCNQ1 钾通道揭示电压感应和孔道开放之间的动态偶联。
Nat Commun. 2017 Nov 23;8(1):1730. doi: 10.1038/s41467-017-01911-8.
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Cryo-EM Structure of a KCNQ1/CaM Complex Reveals Insights into Congenital Long QT Syndrome.KCNQ1/CaM复合物的冷冻电镜结构揭示了对先天性长QT综合征的见解。
Cell. 2017 Jun 1;169(6):1042-1050.e9. doi: 10.1016/j.cell.2017.05.019.
4
Unnatural amino acid photo-crosslinking of the IKs channel complex demonstrates a KCNE1:KCNQ1 stoichiometry of up to 4:4.对IKs通道复合物进行非天然氨基酸光交联实验，结果表明KCNE1与KCNQ1的化学计量比高达4:4。
Elife. 2016 Jan 23;5:e11815. doi: 10.7554/eLife.11815.
5
The KCNQ1 channel - remarkable flexibility in gating allows for functional versatility.KCNQ1通道——门控方面的显著灵活性使其具备功能多样性。
J Physiol. 2015 Jun 15;593(12):2605-15. doi: 10.1113/jphysiol.2014.287607. Epub 2015 Mar 18.
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Domain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channel.结构域间相互作用决定了IKs离子通道的门控、通透、药理学特性及亚基调节。
Elife. 2014 Dec 23;3:e03606. doi: 10.7554/eLife.03606.
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Building KCNQ1/KCNE1 channel models and probing their interactions by molecular-dynamics simulations.基于分子动力学模拟构建 KCNQ1/KCNE1 通道模型并探测其相互作用。
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Single-channel basis for the slow activation of the repolarizing cardiac potassium current, I(Ks).单通道基础上的复极化型钾电流缓慢激活，I(Ks)。
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