Roumane Ahlima, Berthenet Kevin, El Fassi Chaïmaa, Ichim Gabriel
INSERM 1052, CNRS 5286, Cancer Research Center of Lyon (CRCL), Lyon, France.
LabEx DEVweCAN, Université de Lyon, Lyon, France.
BMC Cell Biol. 2018 Jul 4;19(1):11. doi: 10.1186/s12860-018-0164-1.
Apoptosis, the most well-known type of programmed cell death, can induce in a paracrine manner a proliferative response in neighboring surviving cells called apoptosis-induced proliferation (AiP). While having obvious benefits when triggered in developmental processes, AiP is a serious obstacle in cancer therapy, where apoptosis is frequently induced by chemotherapy. Therefore, in this study, we evaluated the capacity of an alternative type of cell death, called caspase-independent cell death, to promote proliferation.
Using a novel in vitro isogenic cellular model to trigger either apoptosis or caspase-independent cell death, we found that the later has no obvious compensatory proliferation effects on neighboring cells.
This study enforces the idea that alternative types of cell death such as caspase-independent cell death could be considered to replace apoptosis in the context of cancer treatment.
凋亡是最广为人知的程序性细胞死亡类型，它能够以旁分泌的方式诱导邻近存活细胞产生增殖反应，即凋亡诱导增殖（AiP）。虽然在发育过程中触发AiP有明显益处，但在癌症治疗中却是一个严重障碍，因为化疗常常会诱导凋亡。因此，在本研究中，我们评估了另一种细胞死亡类型——即不依赖半胱天冬酶的细胞死亡——促进增殖的能力。
使用一种新型的体外同基因细胞模型来触发凋亡或不依赖半胱天冬酶的细胞死亡，我们发现后者对邻近细胞没有明显的代偿性增殖作用。
本研究强化了这样一种观点，即在癌症治疗的背景下，可以考虑用诸如不依赖半胱天冬酶的细胞死亡等其他类型的细胞死亡来替代凋亡。
