在哺乳动物神经垂体中，光散射的大幅快速变化伴随着神经末梢的分泌过程。
Large and rapid changes in light scattering accompany secretion by nerve terminals in the mammalian neurohypophysis.
作者信息
Salzberg B M, Obaid A L, Gainer H
出版信息
J Gen Physiol. 1985 Sep;86(3):395-411. doi: 10.1085/jgp.86.3.395.
Abstract
Large changes in the opacity of the unstained mouse neurohypophysis follow membrane potential changes known to trigger the release of peptide hormones. These intrinsic optical signals, arising in neurosecretory terminals, reflect variations in light scattering and depend upon both the frequency of stimulation and [Ca2+]o. Their magnitude is decreased in the presence of Ca2+ antagonists and by the replacement of H2O in the medium by D2O. These observations suggest a correspondence between the intrinsic optical changes and secretory activity in these nerve terminals.
摘要
未染色的小鼠神经垂体的透明度会随着已知能触发肽类激素释放的膜电位变化而发生显著变化。这些源自神经分泌终末的内在光学信号反映了光散射的变化，并且取决于刺激频率和细胞外钙离子浓度（[Ca2+]o）。在存在钙离子拮抗剂的情况下以及用重水（D2O）替代培养基中的水时，它们的幅度会降低。这些观察结果表明这些神经终末的内在光学变化与分泌活动之间存在对应关系。
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