肾移植受者的斋月禁食：一项单中心回顾性研究。
Ramadan Fasting in Kidney Transplant Recipients: A Single-Centre Retrospective Study.
作者信息
Ibrahim Ihab A, Hassan Ehab A, Alkhan Abdelrahman M, Hussein Mohamed A, Alhabashi Ahmed F, Ali Tariq Z, Shah Yasir Z, Alahmadi Ibrahim S, Abdelsalam Mohamed S, Rashwan Mohamed E, Abdulbaki Ammar, Broering Dieter C, Aleid Hassan A
机构信息
Department of Kidney and Pancreas Transplantation, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Division of Nephrology, Department of Internal Medicine, Cairo University School of Medicine, Cairo, Egypt.
出版信息
J Transplant. 2018 Jun 3;2018:4890978. doi: 10.1155/2018/4890978. eCollection 2018.
BACKGROUND
Fasting during the lunar month of Ramadan is mandatory to all healthy adult Muslims. Renal transplant recipients are often worried about the impact of fluid and electrolyte deprivation during fasting on the function of their allograft. We aimed to examine the effect of fasting Ramadan on the graft function in renal transplant recipients.
METHODS
This retrospective cohort study included patients who underwent kidney transplantation in our tertiary referral center. Baseline pre-Ramadan estimated glomerular filtration rate (eGFR), mean arterial pressure (MAP), and urinary protein excretion were compared to those during and after Ramadan within and between the fasting and non-fasting groups.
RESULTS
The study population included 280 kidney transplant recipients who chose to fast during the Ramadan month (June-July 2014) and 285 recipients who did not fast. In the fasting group, baseline eGFR did not change from that during or post-Ramadan (72.6 ± 23.7 versus 72.3 ± 24.5 mL/min/1.73 m2, = 0.53; and 72.6 ± 23.7 versus 72 ± 23.2 mL/min/1.73 m2, = 0.14, respectively). Compared to baseline, there were no significant differences between the fasting and the non-fasting groups in terms of mean percent changes in eGFR, MAP, and urinary protein excretion.
CONCLUSION
Fasting during the month of Ramadan did not have significant adverse effects on renal allograft function.
背景
所有健康成年穆斯林在斋月期间必须禁食。肾移植受者常常担心禁食期间液体和电解质缺乏对其移植肾功能的影响。我们旨在研究斋月禁食对肾移植受者移植肾功能的影响。
方法
这项回顾性队列研究纳入了在我们的三级转诊中心接受肾移植的患者。将斋月前的基线估计肾小球滤过率（eGFR）、平均动脉压（MAP）和尿蛋白排泄与斋月期间及之后禁食组和非禁食组内部及之间的情况进行比较。
结果
研究人群包括280名选择在斋月期间（2014年6月至7月）禁食的肾移植受者和285名未禁食的受者。在禁食组中，基线eGFR与斋月期间及之后相比没有变化（分别为72.6±23.7对72.3±24.5 mL/min/1.73 m2，P = 0.53；以及72.6±23.7对72±23.2 mL/min/1.73 m2，P = 0.14）。与基线相比，禁食组和非禁食组在eGFR、MAP和尿蛋白排泄的平均百分比变化方面没有显著差异。
结论
斋月期间禁食对移植肾功能没有显著不良影响。
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