Qurashi Salem, Tamimi Abdulrahman, Jaradat Maha, Al Sayyari Abulla
Department of Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
Exp Clin Transplant. 2012 Dec;10(6):551-3. doi: 10.6002/ect.2012.0139. Epub 2012 Aug 24.
To assess the effect of fasting Ramadan during the hottest month of the year in Riyadh, Saudi Arabia.
This prospective cohort study was performed at the King Fahd National Guard Hospital in Riyadh, Saudi Arabia. We used the Modification of Diet in Renal Disease formula to estimate the glomerular filtration rate in renal transplant patients who fasted and did not fast before and after Ramadan.
There were 43 fasters and 37 nonfasters of comparable ages, with fasters having longer posttransplant times compared with nonfasters (P = .0001). The 2 groups had similar mean estimated glomerular filtration rates before Ramadan: 75.6 ± 29.2 and 65.9 ± 25.9 mL/min (P = .1) and similar mean estimated glomerular filtration rates 6 months after Ramadan: 77.2 ± 29.7 and 64.1 ± 29 mL/min (P = .21). Mean changes in the estimated glomerular filtration rate were similar in the 2 groups: -1.5 ± 10.9 and -2.8 ± 19.3 (P = .7) as was the percentage change (-0.2.2 ± 13.4 and 1.8 ± 15.9; P = .4). In the fasting group, serum creatinine and estimated glomerular filtration rate were similar before and 6 months after Ramadan: 105.1 ± 55 and 105.14 ± 61 μmol/L (P = 1.0) and 75.6 ± 29 and 72.2 ± 29.7 mL/min (P = .36). No significant changes were observed in the nonfasting group. No significant differences were detected regarding fasting in the estimated glomerular filtration rate before and 6 months after Ramadan in the 3 groups with the low, moderate, and high glomerular filtration rates at baseline.
Fasting for Ramadan in August does not adversely affect graft function at a mean follow-up of 7.6 ± 1.3 months.
评估在沙特阿拉伯利雅得一年中最热的月份禁食斋月的影响。
这项前瞻性队列研究在沙特阿拉伯利雅得的法赫德国民警卫队医院进行。我们使用肾脏病饮食改良公式来估计斋月前后禁食和未禁食的肾移植患者的肾小球滤过率。
有43名禁食者和37名非禁食者，年龄相仿，与非禁食者相比，禁食者移植后时间更长（P = 0.0001）。两组在斋月前的平均估计肾小球滤过率相似：分别为75.6±29.2和65.9±25.9毫升/分钟（P = 0.1），在斋月后6个月的平均估计肾小球滤过率也相似：分别为77.2±29.7和64.1±29毫升/分钟（P = 0.21）。两组估计肾小球滤过率的平均变化相似：分别为-1.5±10.9和-2.8±19.3（P = 0.7），百分比变化也相似（-0.2±13.4和1.8±15.9；P = 0.4）。在禁食组中，斋月前后血清肌酐和估计肾小球滤过率相似：分别为105.1±55和105.14±61微摩尔/升（P = 1.0）以及75.6±29和72.2±29.7毫升/分钟（P = 0.36）。非禁食组未观察到显著变化。在基线时肾小球滤过率低、中、高的三组中，斋月前后估计肾小球滤过率的禁食情况未检测到显著差异。
在平均随访7.6±1.3个月时，8月禁食斋月对移植肾功能无不利影响。
