Department of Public Health, Faculty of Medicine and Health Sciences, Ghent University, De Pintelaan 185, Block K3-4th floor, 9000, Ghent, Belgium.
GENUD: "Growth, Exercise, Nutrition and Development" Research Group, Facultad de Ciencias de la Salud, University of Zaragoza, Instituto Agroalimentario de Aragón (IA2), Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, Spain.
Eur J Nutr. 2019 Aug;58(5):2051-2065. doi: 10.1007/s00394-018-1764-4. Epub 2018 Jul 4.
To assess if a healthy diet might attenuate the positive sedentary-inflammation relation, whereas an unhealthy diet may increase the effect of sedentary behaviors on inflammatory biomarkers.
In 618 adolescents (13-17 years) of the European HELENA study, data were available on body composition, a set of inflammation markers, and food intake assessed by a self-administered computerized 24 h dietary recall for 2 days. A 9-point Mediterranean diet score and an antioxidant-rich diet z-score were used as dietary indices and tested as moderators. A set of low-grade inflammatory characteristics was used as outcome: several cytokines in an inflammatory ratio (IL-6, IL-10, TNF-α, TGFβ-1), C-reactive protein, three cell-adhesion molecules (sVCAM-1, sICAM-1, sE-selectin), three cardiovascular risk markers (GGT, ALT, homocysteine) and three immune cell types (white blood cells, lymphocytes, CD3). Sedentary behaviors were self-reported and analyzed as total screen time. Multiple linear regression analyses tested moderation by diet in the sedentary behaviors-inflammation association adjusted for age, sex, country, adiposity (sum of six skinfolds), parental education, and socio-economic status.
Both diet scores, Mediterranean and antioxidant-rich diet, were significant protective moderators in the effect of sedentary behaviors on alanine-transaminase enzyme (P = 0.014; P = 0.027), and on the pro/anti-inflammatory cytokine ratio (P = 0.001; P = 0.004), but not on other inflammatory parameters.
A higher adherence to the Mediterranean diet or an antioxidant-rich diet may attenuate the onset of oxidative stress signs associated by sedentary behaviors, whereas a poor diet seems to increase inflammation.
评估健康饮食是否可以减弱积极的久坐-炎症关系，而不健康的饮食可能会增加久坐行为对炎症生物标志物的影响。
在欧洲 HELENA 研究的 618 名青少年（13-17 岁）中，有身体成分、一组炎症标志物和通过自我管理的计算机化 24 小时膳食回忆评估的两天食物摄入量的数据。使用 9 分制地中海饮食评分和富含抗氧化剂的饮食 z 分数作为饮食指数，并作为调节剂进行测试。使用一组低度炎症特征作为结果：炎症比中的几种细胞因子（IL-6、IL-10、TNF-α、TGFβ-1）、C 反应蛋白、三种细胞粘附分子（sVCAM-1、sICAM-1、sE-选择素）、三种心血管风险标志物（GGT、ALT、同型半胱氨酸）和三种免疫细胞类型（白细胞、淋巴细胞、CD3）。久坐行为通过自我报告进行分析，并作为总屏幕时间进行分析。多元线性回归分析测试了在调整年龄、性别、国家、肥胖（6 个皮褶厚度总和）、父母教育程度和社会经济地位后，饮食在久坐行为与炎症关联中的调节作用。
地中海饮食和富含抗氧化剂的饮食评分均为显著的保护性调节剂，可减弱久坐行为对丙氨酸转氨酶酶（P=0.014；P=0.027）的影响，以及对促炎/抗炎细胞因子比（P=0.001；P=0.004）的影响，但对其他炎症参数没有影响。
较高的地中海饮食或富含抗氧化剂的饮食依从性可能会减弱与久坐行为相关的氧化应激迹象的发生，而不良的饮食似乎会增加炎症。
