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在小鼠模型中利用[F]PARPi和氨基酸PET鉴别放射性损伤与复发性肿瘤。

Discriminating radiation injury from recurrent tumor with [F]PARPi and amino acid PET in mouse models.

作者信息

Donabedian Patrick L, Kossatz Susanne, Engelbach John A, Jannetti Stephen A, Carney Brandon, Young Robert J, Weber Wolfgang A, Garbow Joel R, Reiner Thomas

机构信息

Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.

Department of Radiology, Washington University, St. Louis, MO, USA.

出版信息

EJNMMI Res. 2018 Jul 4;8(1):59. doi: 10.1186/s13550-018-0399-z.

DOI:10.1186/s13550-018-0399-z
PMID:29974335
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6031550/
Abstract

BACKGROUND

Radiation injury can be indistinguishable from recurrent tumor on standard imaging. Current protocols for this differential diagnosis require one or more follow-up imaging studies, long dynamic acquisitions, or complex image post-processing; despite much research, the inability to confidently distinguish between these two entities continues to pose a significant dilemma for the treating clinician. Using mouse models of both glioblastoma and radiation necrosis, we tested the potential of poly(ADP-ribose) polymerase (PARP)-targeted PET imaging with [F]PARPi to better discriminate radiation injury from tumor.

RESULTS

In mice with experimental radiation necrosis, lesion uptake on [F]PARPi-PET was similar to contralateral uptake (1.02 ± 0.26 lesion/contralateral %IA/cc ratio), while [F]FET-PET clearly delineated the contrast-enhancing region on MR (2.12 ± 0.16 lesion/contralateral %IA/cc ratio). In mice with focal intracranial U251 xenografts, tumor visualization on PARPi-PET was superior to FET-PET, and lesion-to-contralateral activity ratios (max/max, p = 0.034) were higher on PARPi-PET than on FET-PET.

CONCLUSIONS

A murine model of radiation necrosis does not demonstrate [F]PARPi avidity, and [F]PARPi-PET is better than [F]FET-PET in distinguishing radiation injury from brain tumor. [F]PARPi-PET can be used for discrimination between recurrent tumor and radiation injury within a single, static imaging session, which may be of value to resolve a common dilemma in neuro-oncology.

摘要

背景

在标准成像上，放射性损伤可能与复发性肿瘤难以区分。目前用于这种鉴别诊断的方案需要一项或多项随访成像研究、长时间动态采集或复杂的图像后处理；尽管进行了大量研究，但无法可靠地区分这两种情况仍然给临床治疗医生带来重大困境。我们使用胶质母细胞瘤和放射性坏死的小鼠模型，测试了用[F]PARPi进行聚（ADP-核糖）聚合酶（PARP）靶向PET成像以更好地区分放射性损伤和肿瘤的潜力。

结果

在实验性放射性坏死的小鼠中，[F]PARPi-PET上病变摄取与对侧摄取相似（病变/对侧%IA/cc比值为1.02±0.26），而[F]FET-PET在磁共振成像上清晰勾勒出强化区域（病变/对侧%IA/cc比值为2.12±0.16）。在局灶性颅内U251异种移植小鼠中，PARPi-PET上的肿瘤可视化优于FET-PET，PARPi-PET上的病变与对侧活性比值（最大值/最大值，p=0.034）高于FET-PET。

结论

放射性坏死的小鼠模型未显示[F]PARPi亲和力，[F]PARPi-PET在区分放射性损伤和脑肿瘤方面优于[F]FET-PET。[F]PARPi-PET可用于在单次静态成像过程中区分复发性肿瘤和放射性损伤，这可能有助于解决神经肿瘤学中的一个常见难题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b939/6031550/767d03ceafe2/13550_2018_399_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b939/6031550/ab1e1ccb3661/13550_2018_399_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b939/6031550/46c37b644b7d/13550_2018_399_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b939/6031550/a6d6f24737dc/13550_2018_399_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b939/6031550/0ff827fdd4ae/13550_2018_399_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b939/6031550/767d03ceafe2/13550_2018_399_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b939/6031550/ab1e1ccb3661/13550_2018_399_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b939/6031550/46c37b644b7d/13550_2018_399_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b939/6031550/a6d6f24737dc/13550_2018_399_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b939/6031550/0ff827fdd4ae/13550_2018_399_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b939/6031550/767d03ceafe2/13550_2018_399_Fig5_HTML.jpg

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