Goldraich N P, Alvarenga A R, Goldraich I H, Ramos O L, Sigulem D
J Urol. 1985 Dec;134(6):1282-6. doi: 10.1016/s0022-5347(17)47712-3.
In order to investigate aspects of the renal handling of 99mTc-DMSA, 68 isolated rat kidneys were artificially perfused. The experimental groups were: Group 1 (no. = 32)-oxygenated filtering kidneys; Group 2 (no. = 29)-oxygenated non-filtering kidneys; Group 3 (no. = 7)-anaerobic non-filtering kidneys. We conclude that the 99mTc-DMSA complex is strongly bound to albumin, is not filtered and is removed from perfusion fluid through the renal peritubular capillary route and that this occurs by an active process which depends upon aerobic metabolism. This process has a high capacity and is not inhibited by probenecid.
为了研究99mTc-DMSA的肾脏处理情况，对68个离体大鼠肾脏进行了人工灌注。实验组包括：第1组（n = 32）——充氧的滤过肾脏；第2组（n = 29）——充氧的非滤过肾脏；第3组（n = 7）——厌氧的非滤过肾脏。我们得出结论，99mTc-DMSA复合物与白蛋白紧密结合，不被滤过，通过肾周毛细血管途径从灌注液中清除，并且这一过程是通过依赖有氧代谢的主动过程发生的。该过程具有高容量，且不受丙磺舒抑制。
