钯催化的苯膦酸酯的去芳构化烯丙基化反应。
Pd-Catalyzed Dearomative Allylation of Benzyl Phosphates.
机构信息
Department of Applied Chemistry , Waseda University , 3-4-1 Ohkubo , Shinjuku, Tokyo 169-8555 , Japan.
出版信息
Org Lett. 2018 Jul 20;20(14):4354-4357. doi: 10.1021/acs.orglett.8b01807. Epub 2018 Jul 5.
PMID:29975060
Abstract
Dearomative C-C bond formation of benzyl phosphates has been developed. In the presence of a palladium/PAr catalyst, benzyl phosphates reacted with allyl borates to generate the allylated product in a dearomative fashion. The resulting dearomatized molecules were successfully derivatized by Simmons-Smith cyclopropanation and oxidation.
摘要
发展了去芳构化的 C-C 键形成反应，使苄基磷酸酯与烯丙基硼酸酯在钯/PAr 催化剂作用下发生反应，以去芳构化的方式生成烯丙基化产物。所得去芳构化分子可进一步通过 Simmons-Smith 环丙烷化和氧化反应进行衍生化。
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