使用氘代对甲苯磺酸三氘代甲基对芳基卤化物的镍和亲核钴催化的三氘代甲基化。
Nickel and Nucleophilic Cobalt-Catalyzed Trideuteriomethylation of Aryl Halides Using Trideuteriomethyl p-Toluenesulfonate.
机构信息
Department of Applied Chemistry, Graduate School of Engineering , Hiroshima University , Higashi-Hiroshima City 739-8527 , Japan.
出版信息
Org Lett. 2018 Jul 20;20(14):4375-4378. doi: 10.1021/acs.orglett.8b01863. Epub 2018 Jul 5.
PMID:29975070
Abstract
Herein, a novel approach for the trideuteriomethylation of aryl halides using nickel and nucleophilic cobalt catalysts and the readily available trideuteriomethyl p-toluenesulfonate (CDOTs) is described. This method provides access to a wide range of CD-containing arenes. Moreover, a transmethylation step is revealed as crucial in the nickel/cobalt catalytic mechanism.
摘要
本文描述了一种使用镍和亲核钴催化剂以及易得的氘代对甲苯磺酸三氘甲酯（CDOTs）对芳基卤化物进行 trideuteriomethylation 的新方法。该方法可获得广泛的含 CD 的芳族化合物。此外，揭示了转甲基步骤在镍/钴催化机制中至关重要。
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