Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota.
Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Cancer. 2018 Sep 1;124(17):3560-3566. doi: 10.1002/cncr.31592. Epub 2018 Jul 5.
Minnesota has the second largest Hmong population in the United States. The objective of the current study was to estimate the cancer incidence among Hmong individuals in Minnesota between 2000 and 2012 to determine targets for screening and interventions.
Cancer cases in Minnesota between 2000 and 2012 were obtained from the Minnesota Cancer Surveillance System, and proportional incidence ratios (PIRs) were calculated. The 2000 and 2010 US Census reports were used to obtain total population estimates. Age-adjusted cancer incidence rates (AAR) and 95% confidence intervals (95% CIs) were calculated for Hmong individuals, Asian/Pacific Islander individuals, and all Minnesotans using direct method and Poisson regression.
Compared with all Minnesotans, the Hmong had elevated PIRs and AARs for malignancies related to infections, including nasopharyngeal, stomach, liver, and cervical cancers. The AAR ratios in Hmong versus all Minnesotans were found to be significantly increased for nasopharyngeal (AAR, 15.90; 95% CI, 9.48-26.68), stomach (AAR, 2.99; 95% CI, 2.06-4.33), liver (AAR, 1.77; 95% CI, 1.04-3.02), and cervical (AAR, 3.88; 95% CI, 2.61-5.77) cancers. The AARs in Hmong versus all Minnesotans were significantly lower for all-cause cancer (AAR, 0.39; 95% CI, 0.35-0.44); cancers of the breast, lung, and colorectum; melanoma; and non-Hodgkin lymphoma. Compared with Asian/Pacific Islander individuals, the rates in Hmong were significantly higher for melanoma and cervical cancer, with AAR ratios of 2.23 (95% CI, 1.09-4.56) and 1.59 (95% CI, 1.01-2.49), respectively.
Compared with all Minnesotans, the Hmong have an increased incidence of cancers related to infectious agents. These findings indicate a need for cancer prevention and screening programs in this population.
明尼苏达州拥有美国第二大的苗族人口。本研究的目的是估计 2000 年至 2012 年期间明尼苏达州苗族人群的癌症发病率，以确定筛查和干预的目标。
从明尼苏达州癌症监测系统获取 2000 年至 2012 年期间明尼苏达州的癌症病例，并计算比例发病率比（PIR）。使用 2000 年和 2010 年美国人口普查报告获得总人口估计数。使用直接法和泊松回归计算苗族、亚裔/太平洋岛民和所有明尼苏达州人年龄调整后的癌症发病率（AAR）和 95%置信区间（95%CI）。
与所有明尼苏达州人相比，苗族人群的感染相关恶性肿瘤（包括鼻咽癌、胃癌、肝癌和宫颈癌）的 PIR 和 AAR 较高。与所有明尼苏达州人相比，苗族人群的鼻咽癌（AAR，15.90；95%CI，9.48-26.68）、胃癌（AAR，2.99；95%CI，2.06-4.33）、肝癌（AAR，1.77；95%CI，1.04-3.02）和宫颈癌（AAR，3.88；95%CI，2.61-5.77）的 AAR 比值明显增加。与所有明尼苏达州人相比，苗族人群的所有原因癌症（AAR，0.39；95%CI，0.35-0.44）、乳腺癌、肺癌和结直肠癌、黑色素瘤和非霍奇金淋巴瘤的 AAR 比值明显较低。与亚裔/太平洋岛民相比，苗族人群的黑色素瘤和宫颈癌发病率明显较高，AAR 比值分别为 2.23（95%CI，1.09-4.56）和 1.59（95%CI，1.01-2.49）。
与所有明尼苏达州人相比，苗族人群的感染相关癌症发病率增加。这些发现表明，需要在该人群中开展癌症预防和筛查计划。
