The Sainsbury Laboratory, Norwich Research Park, Norwich, NR4 7UH, United Kingdom; email:
Annu Rev Phytopathol. 2018 Aug 25;56:479-512. doi: 10.1146/annurev-phyto-080417-050158. Epub 2018 Jul 5.
Genome editing by sequence-specific nucleases (SSNs) has revolutionized biology by enabling targeted modifications of genomes. Although routine plant genome editing emerged only a few years ago, we are already witnessing the first applications to improve disease resistance. In particular, CRISPR-Cas9 has democratized the use of genome editing in plants thanks to the ease and robustness of this method. Here, we review the recent developments in plant genome editing and its application to enhancing disease resistance against plant pathogens. In the future, bioedited disease resistant crops will become a standard tool in plant breeding.
序列特异性核酸酶（SSNs）的基因组编辑通过靶向基因组修饰彻底改变了生物学。尽管常规的植物基因组编辑仅在几年前出现，但我们已经看到了第一个应用来提高抗病性的例子。特别是，CRISPR-Cas9 由于其方法的简便性和稳健性，使基因组编辑在植物中的应用变得更加普及。在这里，我们回顾了植物基因组编辑的最新进展及其在提高植物病原体抗性方面的应用。在未来，生物编辑的抗病作物将成为植物育种的标准工具。
