诱导多能干细胞模型中的小胶质细胞功能：最新进展。

Modelling microglial function with induced pluripotent stem cells: an update.

机构信息

Department of Neuroinflammation, University College London Institute of Neurology, London, UK.

出版信息

Nat Rev Neurosci. 2018 Aug;19(8):445-452. doi: 10.1038/s41583-018-0030-3.

Abstract

It is becoming increasingly apparent that microglia, the immune cells of the CNS, and their peripheral counterparts, macrophages, have a major role in normal physiology and pathology. Recent technological advances in the production of particular cell types from induced pluripotent stem cells have led to an interest in applying this methodology to the production of microglia. Here, we discuss recent advances in this area and describe how they will aid our future understanding of microglia.

摘要

越来越明显的是，中枢神经系统的免疫细胞——小胶质细胞及其外周对应物——巨噬细胞，在正常生理和病理中发挥着重要作用。最近在诱导多能干细胞中产生特定细胞类型的技术进步，促使人们产生了将这种方法应用于小胶质细胞产生的兴趣。在这里，我们讨论了这一领域的最新进展，并描述了它们将如何帮助我们未来更好地理解小胶质细胞。