酵母II类转座子Ty 1-17的核苷酸序列特征
Nucleotide sequence characterization of Ty 1-17, a class II transposon from yeast.
作者信息
Warmington J R, Waring R B, Newlon C S, Indge K J, Oliver S G
出版信息
Nucleic Acids Res. 1985 Sep 25;13(18):6679-93. doi: 10.1093/nar/13.18.6679.
Abstract
We have determined the nucleotide sequence of a class II yeast transposon (Ty 1-17) which is found just centromere-distal to the LEU2 structural gene on chromosome III of Saccharomyces cerevisiae. The complete element is 5961 bp long and is bounded by two identical, directly repeated, delta sequences of 332 bp each. The sequence organization indicates that Ty 1-17 is a retrotransposon, like the class I elements characterized previously. It contains two long open reading-frames, TyA (439 amino acids) and TyB (1349 amino acids). In this paper, the sequences of the two classes of yeast transposon are compared with one another and with analogous elements, such as retroviral proviruses, cauliflower mosaic virus and copia sequences. Features of the Ty 1-17 sequence which may be important to its mechanism of transposition and its genetic action are discussed.
摘要
我们已经确定了一种II类酵母转座子（Ty 1-17）的核苷酸序列，该转座子位于酿酒酵母III号染色体上LEU2结构基因着丝粒远端。完整元件长5961 bp，由两个相同的、直接重复的δ序列界定，每个δ序列长332 bp。序列组织表明Ty 1-17是一种逆转座子，类似于先前鉴定的I类元件。它包含两个长开放阅读框，TyA（439个氨基酸）和TyB（1349个氨基酸）。本文将两类酵母转座子的序列相互比较，并与类似元件进行比较，如逆转录病毒前病毒、花椰菜花叶病毒和copia序列。讨论了Ty 1-17序列中可能对其转座机制及其遗传作用很重要的特征。
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