Lee Dong-Hyun, Park Ki Soo, Cho Min-Chul
Department of Laboratory Medicine, Gyeongsang National University Hospital Department of Preventive Medicine, Gyeongsang National University College of Medicine Institute of Health Sciences, Gyeongsang National University Center of Farmer's Safety and Health Department of Laboratory Medicine, Gyeongsang National University College of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea.
Medicine (Baltimore). 2018 Jul;97(27):e11419. doi: 10.1097/MD.0000000000011419.
Vitamin D concentration is known to correlate with various parameters. A major source of vitamin D is synthesis in the skin; thus, the duration of sun exposure is known to correlate with serum vitamin D levels. We compared serum levels of vitamin D between 2 occupational groups in Korea: the fisherman group, the most sun-exposed, and the general occupation group, relatively less sun-exposed. This study was conducted on 140 healthy fishermen and 140 healthy residents with various occupations, all of whom resided in the southernmost region of Korea, from June to August 2016. We compared serum concentrations of 25-hydroxyvitamin D (25(OH)D) in both occupation groups by gender and age and suggested vitamin D reference interval for the region. Mean serum 25(OH)D concentrations in the general occupation and fisherman group were 13.60 ± 6.43 and 23.74 ± 8.88 ng/mL, respectively. Mean serum concentration of 25(OH)D was 1.7 times higher in the fisherman group compared with the general occupation group, which was statistically significant (P < .001). Approximately 98% of subjects in the general occupation group and 78% of subjects in the fisherman group demonstrated either vitamin D insufficiency or deficiency. Calculated serum 25(OH)D reference interval for all subjects in our study was 3.8 to 44.4 ng/mL. Despite exposure to a large amount of sunlight, 78% of subjects in the fisherman group presented with either vitamin D deficiency or insufficiency. By taking laboratory measurements of serum 25(OH)D concentrations in fisherman, who were expected to have the highest vitamin D concentrations in Korea, this study could be epidemiologically useful.
已知维生素D浓度与各种参数相关。维生素D的一个主要来源是皮肤合成；因此，日照时长已知与血清维生素D水平相关。我们比较了韩国两个职业群体的血清维生素D水平：渔民群体，日照最多；一般职业群体，日照相对较少。本研究于2016年6月至8月对140名健康渔民和140名从事各种职业的健康居民进行，他们均居住在韩国最南端地区。我们按性别和年龄比较了两个职业群体中25-羟基维生素D（25(OH)D）的血清浓度，并提出了该地区的维生素D参考区间。一般职业群体和渔民群体的血清25(OH)D平均浓度分别为13.60±6.43和23.74±8.88 ng/mL。渔民群体的血清25(OH)D平均浓度比一般职业群体高1.7倍，具有统计学意义（P<0.001）。一般职业群体中约98%的受试者和渔民群体中78%的受试者表现出维生素D不足或缺乏。我们研究中所有受试者的血清25(OH)D参考区间经计算为3.8至44.4 ng/mL。尽管暴露于大量阳光下，但渔民群体中78%的受试者仍存在维生素D缺乏或不足。通过对预计维生素D浓度在韩国最高的渔民进行血清25(OH)D浓度的实验室测量，本研究在流行病学上可能具有重要意义。
