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用单克隆抗体探测的爱泼斯坦-巴尔病毒核抗原的结构

Structure of the Epstein-Barr virus nuclear antigen as probed with monoclonal antibodies.

作者信息

Hearing J C, Lewis A, Levine A J

出版信息

Virology. 1985 Apr 15;142(1):215-20. doi: 10.1016/0042-6822(85)90436-2.

Abstract

Five hybridoma cell lines secreting antibodies directed against an Epstein-Barr virus (EBV) nuclear antigen (BamHI K antigen) have been isolated. All five antibodies detect this antigen in a variety of EBV-positive lymphoblastoid cell lines. The reaction of these antibodies with several mutant forms of this protein has allowed the antibody binding site(s) to be predicted.

摘要

已分离出五种分泌针对爱泼斯坦-巴尔病毒(EBV)核抗原(BamHI K抗原)抗体的杂交瘤细胞系。所有这五种抗体均可在多种EBV阳性淋巴母细胞系中检测到该抗原。这些抗体与该蛋白的几种突变形式的反应使得能够预测抗体结合位点。

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