哮喘儿童对地中海饮食的依从性与炎症标志物

Adherence to the Mediterranean diet and inflammatory markers in children with asthma.

作者信息

Douros Konstantinos, Thanopoulou Maria-Ioanna, Boutopoulou Barbara, Papadopoulou Anna, Papadimitriou Anastassios, Fretzayas Andrew, Priftis Kostas N

机构信息

Children's Respiratory and Allergy Clinic, 3(rd) Dept of Paediatrics, National and Kapodistrian University of Athens, "Attikon" General University Hospital, Athens, Greece.

出版信息

Allergol Immunopathol (Madr). 2019 May-Jun;47(3):209-213. doi: 10.1016/j.aller.2018.04.007. Epub 2018 Jul 3.

DOI:10.1016/j.aller.2018.04.007

PMID:29980401

Abstract

INTRODUCTION

There is accumulated evidence supporting a beneficial role of Mediterranean diet (MD) in the control of asthma symptoms. The aim of this study was to investigate the relationships between adherence to MD and serum levels of certain cytokines namely, interleukin (IL)-4, and IL-17 known to have a pathogenetic role in the airway changes associated with asthma.

METHODS

We measured serum IL-4, IL-33, and IL-17, in 44 asthmatic and 26 healthy children, 5-15 years old. Their adherence to MD was estimated with the Mediterranean Diet Quality Index for children and adolescents (KIDMED) score.

RESULTS

KIDMED score did not differ between the two groups (P=0.59) and was not correlated with any of the three measured cytokines. However, when the analysis was restricted only to asthmatic children, the KIDMED score was correlated with IL-4, IL-33, and IL-17 (Beta: -0.56, P=0.007; Beta: 0.57, P=0.010; Beta: -0.62, P=0.017, respectively).

CONCLUSION

Our results indicate that MD can modulate the production of some of the main inflammatory mediators of asthma, in asthmatic children.

摘要

引言

有越来越多的证据支持地中海饮食（MD）在控制哮喘症状方面具有有益作用。本研究的目的是调查坚持地中海饮食与某些细胞因子血清水平之间的关系，这些细胞因子即白细胞介素（IL）-4和IL-17，已知它们在与哮喘相关的气道变化中具有致病作用。

方法

我们测量了44名5至15岁哮喘儿童和26名健康儿童的血清IL-4、IL-33和IL-17。用儿童和青少年地中海饮食质量指数（KIDMED）评分来评估他们对地中海饮食的坚持程度。

结果

两组之间的KIDMED评分没有差异（P = 0.59），并且与所测量的三种细胞因子中的任何一种均无相关性。然而，当分析仅限于哮喘儿童时，KIDMED评分与IL-4、IL-33和IL-17相关（β分别为：-0.56，P = 0.007；β为：0.57，P = 0.010；β为：-0.62，P = 0.017）。