健身与肥胖对心血管疾病死亡率的联合影响：一项荟萃分析。
The Joint Association of Fitness and Fatness on Cardiovascular Disease Mortality: A Meta-Analysis.
机构信息
Health and Human Performance, Middle Tennessee State University, Murfreesboro, TN, United States of America.
Health and Human Performance, Middle Tennessee State University, Murfreesboro, TN, United States of America.
出版信息
Prog Cardiovasc Dis. 2018 Jul-Aug;61(2):136-141. doi: 10.1016/j.pcad.2018.07.004. Epub 2018 Jul 5.
The joint association of cardiorespiratory fitness (CRF) and body mass index (BMI) on cardiovascular disease (CVD) mortality was determined. PubMed and CINAHL were searched following PRISMA guidelines. Included studies were prospective, had objective assessments of maximal CRF and BMI, and compared the joint impact of CRF and BMI on CVD mortality risk to normal weight, fit referents. Pooled hazard ratios and 95% confidence intervals were calculated from eight articles with nine independent groups using a random effects model. Unfit individuals had two to three times the risk of mortality across all levels of BMI. Overweight and obese-fit individuals had 25% and 42% increased mortality risk, respectively, compared to normal weight-fit individuals. However, for the obese-fit group, a one study removed analysis for five studies resulted in non-significant changes in mortality risk. Researchers, clinicians, and public health officials are encouraged to employ CRF interventions to reduce CDV mortality risk.
研究了心肺适能（CRF）和体重指数（BMI）联合对心血管疾病（CVD）死亡率的影响。按照 PRISMA 指南，检索了 PubMed 和 CINAHL。纳入的研究为前瞻性研究，对最大 CRF 和 BMI 进行了客观评估，并将 CRF 和 BMI 对 CVD 死亡率风险的联合影响与正常体重、健康参考进行了比较。使用随机效应模型，对来自八篇文章的九个独立组进行了荟萃分析，计算了合并风险比和 95%置信区间。在所有 BMI 水平下，不适合的个体的死亡率风险增加了两倍到三倍。与正常体重、健康的个体相比，超重和肥胖、健康的个体的死亡率风险分别增加了 25%和 42%。然而，对于肥胖、健康的个体，五项研究中剔除一项研究的分析后，死亡率风险的变化没有统计学意义。鼓励研究人员、临床医生和公共卫生官员采用 CRF 干预措施来降低 CVD 死亡率风险。
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