类风湿关节炎和干燥综合征中巨细胞病毒与EB病毒的血清流行病学研究。
A seroepidemiological study of cytomegalovirus and Epstein-Barr virus in rheumatoid arthritis and sicca syndrome.
作者信息
Venables P J, Ross M G, Charles P J, Melsom R D, Griffiths P D, Maini R N
出版信息
Ann Rheum Dis. 1985 Nov;44(11):742-6. doi: 10.1136/ard.44.11.742.
Abstract
Antibodies to cytomegalovirus (CMV) and Epstein-Barr virus capsid antigen (EBVCA) were examined in 41 patients with rheumatoid arthritis (RA), 26 patients with primary sicca syndrome, and 26 healthy subjects of similar age and sex. IgG antibody titres to EBVCA and CMV were similar in all three groups, apart from a trivial increase of antibodies to EBVCA in RA. False positive IgM anti-CMV antibodies detected in serum from one patient with sicca syndrome and 20 patients with RA were shown to be due to rheumatoid factors. These data did not support recent suggestions that patients with these diseases showed exaggerated immunological responses to either virus and emphasised the need to incorporate adequate laboratory and disease controls when seroepidemiological studies are performed on sera containing rheumatoid factors and autoantibodies.
摘要
对41例类风湿关节炎（RA）患者、26例原发性干燥综合征患者以及26名年龄和性别相仿的健康受试者检测了抗巨细胞病毒（CMV）抗体和抗爱泼斯坦-巴尔病毒衣壳抗原（EBVCA）抗体。除了RA患者中抗EBVCA抗体有轻微升高外，三组中抗EBVCA和CMV的IgG抗体滴度相似。在1例干燥综合征患者和20例RA患者血清中检测到的假阳性IgM抗CMV抗体被证实是由类风湿因子所致。这些数据不支持近期关于这些疾病患者对这两种病毒均表现出过度免疫反应的观点，并强调在对含有类风湿因子和自身抗体的血清进行血清流行病学研究时，需要纳入适当的实验室对照和疾病对照。
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