干燥综合征和非特异性涎腺炎患者唇唾液腺中巨细胞病毒和EB病毒的检测
Detection of cytomegalovirus and Epstein-Barr virus in labial salivary glands in Sjogren's syndrome and non-specific sialadenitis.
作者信息
Maitland N, Flint S, Scully C, Crean S J
机构信息
Department of Biology, University of York, England.
出版信息
J Oral Pathol Med. 1995 Aug;24(7):293-8. doi: 10.1111/j.1600-0714.1995.tb01187.x.
Abstract
To investigate the role of herpes viruses in Sjogren's syndrome, minor (labial) salivary gland tissues from Sjogren's syndrome and from non-specific sialadenitis were examined for Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) DNA by the polymerase chain reaction. Almost half of all salivary glands studied contained EBV and/or HCMV. There was, however, no significant difference between the detection of EBV or HCMV in salivary glands from patients with Sjogren's syndrome or non-specific sialadenitis. The findings are consistent with the persistence of EBV and HCMV in minor salivary glands following primary infection, but do not indicate a direct role for either virus in the aetiology of Sjogren's syndrome, and do not exclude reactivation of the viruses in this disease.
摘要
为研究疱疹病毒在干燥综合征中的作用，通过聚合酶链反应对干燥综合征患者及非特异性涎腺炎患者的小（唇）唾液腺组织进行了爱泼斯坦-巴尔病毒（EBV）和人巨细胞病毒（HCMV）DNA检测。几乎一半的被研究唾液腺含有EBV和/或HCMV。然而，干燥综合征患者与非特异性涎腺炎患者唾液腺中EBV或HCMV的检测结果并无显著差异。这些发现与初次感染后EBV和HCMV在小唾液腺中的持续存在相一致，但并未表明这两种病毒在干燥综合征病因学中具有直接作用，也未排除这些病毒在该疾病中的再激活。
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