唾液蛋白糖基化进展及其与全身和口腔疾病的关系
[Advances in salivary protein glycosylation and its relationship with systemic and oral diseases].
作者信息
Ma Rui, Peng Xian, Xu Yi, Duan Ding-Yu
机构信息
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
出版信息
Hua Xi Kou Qiang Yi Xue Za Zhi. 2018 Jun 1;36(3):336-341. doi: 10.7518/hxkq.2018.03.020.
Protein glycosylation is one of the most important protein post-translational modifications that can affect life activities by endowing the protein with various structural and functional features. Saliva is an easy-to-obtain, noninvasive body fluid that contains components originating from serum, gingival crevicular fluid, and oropharyngeal mucosae. In recent years, understanding of saliva has been constantly updated with the developments in related research. Studies have shown that salivary proteins can be used as diagnostic markers for certain diseases, and changes of protein glycosylation in saliva are generally considered to be related to many diseases. In this review, salivary protein glycosylation and its relationship with systemic and oral diseases were discussed.
蛋白质糖基化是最重要的蛋白质翻译后修饰之一，它能赋予蛋白质各种结构和功能特征，从而影响生命活动。唾液是一种易于获取的无创体液，含有源自血清、龈沟液和口咽黏膜的成分。近年来，随着相关研究的发展，对唾液的认识不断更新。研究表明，唾液蛋白可作为某些疾病的诊断标志物，唾液中蛋白质糖基化的变化通常被认为与多种疾病有关。本文综述了唾液蛋白糖基化及其与全身疾病和口腔疾病的关系。
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