• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

高密度基因分型揭示了印度大额牛（Bos frontalis）的基因组特征、群体结构和遗传多样性。

High-density Genotyping reveals Genomic Characterization, Population Structure and Genetic Diversity of Indian Mithun (Bos frontalis).

机构信息

Animal Genetics and Breeding Lab., ICAR-National Research Centre on Mithun, Medziphema, Nagaland, 797106, India.

Dairy Cattle Breeding Division, ICAR-National Dairy Research Institute, Karnal, Haryana, 132001, India.

出版信息

Sci Rep. 2018 Jul 9;8(1):10316. doi: 10.1038/s41598-018-28718-x.

DOI:10.1038/s41598-018-28718-x
PMID:29985484
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6037757/
Abstract

The current study aimed at genomic characterization and improved understanding of genetic diversity of two Indian mithun populations (both farm, 48 animals and field, 24 animals) using genome wide genotype data generated with Illumina BovineHD BeadChip. Eight additional populations of taurine cattle (Holstein and NDama), indicine cattle (Gir) and other evolutionarily closely related species (Bali cattle, Yak, Bison, Gaur and wild buffalo) were also included in this analysis (N = 137) for comparative purposes. Our results show that the genetic background of mithun populations was uniform with few possible signs of indicine admixture. In general, observed and expected heterozygosities were quite similar in these two populations. We also observed increased frequencies of small-sized runs of homozygosity (ROH) in the farm population compared to field mithuns. On the other hand, longer ROH were more frequent in field mithuns, which suggests recent founder effects and subsequent genetic drift due to close breeding in farmer herds. This represents the first study providing genetic evidence about the population structure and genomic diversity of Indian mithun. The information generated will be utilized for devising suitable breeding and conservation programme for mithun, an endangered bovine species in India.

摘要

本研究旨在利用 Illumina BovineHD BeadChip 生成的全基因组基因型数据，对两个印度大额牛种群（均为农场种群，48 只动物和野外种群，24 只动物）进行基因组特征分析和遗传多样性的深入了解。此外，还包括了 8 个其他的牛种群体（荷斯坦和 NDama）、印度牛种（Gir）和其他进化上密切相关的物种（巴厘牛、牦牛、野牛、白肢野牛和野生水牛）（N=137）进行比较分析。我们的结果表明，大额牛种群的遗传背景是一致的，只有少数印度牛种的混杂迹象。一般来说，这两个种群的观察到的和预期的杂合度非常相似。我们还观察到，与野外大额牛相比，农场种群中小长度的纯合子区域（ROH）的频率增加。另一方面，在野外大额牛中，更长的 ROH 更为常见，这表明由于农民群体中的近亲繁殖，最近发生了奠基者效应和随后的遗传漂变。这是首次提供关于印度大额牛种群结构和基因组多样性的遗传证据的研究。所产生的信息将用于制定适合印度大额牛的育种和保护计划，因为印度大额牛是一种濒危的牛种。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa0c/6037757/4d80c19911f4/41598_2018_28718_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa0c/6037757/5467d5d9b013/41598_2018_28718_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa0c/6037757/27b92acce991/41598_2018_28718_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa0c/6037757/81f72dba2f09/41598_2018_28718_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa0c/6037757/78dbeee934f1/41598_2018_28718_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa0c/6037757/e4f1f5316e3c/41598_2018_28718_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa0c/6037757/4d80c19911f4/41598_2018_28718_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa0c/6037757/5467d5d9b013/41598_2018_28718_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa0c/6037757/27b92acce991/41598_2018_28718_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa0c/6037757/81f72dba2f09/41598_2018_28718_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa0c/6037757/78dbeee934f1/41598_2018_28718_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa0c/6037757/e4f1f5316e3c/41598_2018_28718_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa0c/6037757/4d80c19911f4/41598_2018_28718_Fig6_HTML.jpg

相似文献

1
High-density Genotyping reveals Genomic Characterization, Population Structure and Genetic Diversity of Indian Mithun (Bos frontalis).高密度基因分型揭示了印度大额牛（Bos frontalis）的基因组特征、群体结构和遗传多样性。
Sci Rep. 2018 Jul 9;8(1):10316. doi: 10.1038/s41598-018-28718-x.
2
Complete mitochondrial genome of Indian mithun, Bos frontalis and its phylogenetic implications.印度野牛（Bos frontalis）的线粒体全基因组及其系统发育意义
Mol Biol Rep. 2019 Apr;46(2):2561-2566. doi: 10.1007/s11033-019-04675-0. Epub 2019 Feb 14.
3
Diversity and phylogeny of mitochondrial DNA isolated from mithun Bos frontalis located in Bhutan.从位于不丹的野牛线粒体 DNA 中分离出的多样性和系统发育。
Anim Genet. 2010 Oct;41(5):554-6. doi: 10.1111/j.1365-2052.2010.02033.x.
4
Milk protein polymorphisms in cattle (Bos indicus), mithun (Bos frontalis) and yak (Bos grunniens) breeds and their hybrids indigenous to Bhutan.牛（印度野牛）、野牛（印度野牛）和牦牛（野牦牛）品种以及原产于不丹的这些品种的杂种牛的乳蛋白多态性。
Anim Sci J. 2010 Oct;81(5):523-9. doi: 10.1111/j.1740-0929.2010.00790.x. Epub 2010 Sep 20.
5
Low levels of taurine introgression in the current Brazilian Nelore and Gir indicine cattle populations.在当前巴西瘤牛和吉尔牛种群中，牛磺酸渗入水平较低。
Genet Sel Evol. 2015 Apr 17;47(1):31. doi: 10.1186/s12711-015-0109-5.
6
Whole genome sequence and de novo assembly revealed genomic architecture of Indian Mithun (Bos frontalis).全基因组序列和从头组装揭示了印度大额牛（Bos frontalis）的基因组结构。
BMC Genomics. 2019 Jul 29;20(1):617. doi: 10.1186/s12864-019-5980-y.
7
Genomic inbreeding estimation in small populations: evaluation of runs of homozygosity in three local dairy cattle breeds.小群体中基因组近亲繁殖估计：对三个本地奶牛品种纯合子连续片段的评估
Animal. 2016 May;10(5):746-54. doi: 10.1017/S1751731115002943. Epub 2016 Jan 6.
8
Novel polymorphisms in UTR and coding region of inducible heat shock protein 70.1 gene in tropically adapted Indian zebu cattle (Bos indicus) and riverine buffalo (Bubalus bubalis).热带适应性印度瘤牛（Bos indicus）和沼泽型水牛（Bubalus bubalis）中诱导型热休克蛋白 70.1 基因 UTR 和编码区的新型多态性。
Gene. 2013 Sep 25;527(2):606-15. doi: 10.1016/j.gene.2013.05.078. Epub 2013 Jun 19.
9
Genetic characterization of a herd of the endangered Danish Jutland cattle.一群濒危丹麦日德兰牛的基因特征分析。
J Anim Sci. 2014 Jun;92(6):2372-6. doi: 10.2527/jas.2013-7206. Epub 2014 Mar 26.
10
Genome-wide genetic diversity, population structure and admixture analysis in African and Asian cattle breeds.非洲和亚洲牛品种的全基因组遗传多样性、种群结构及混合分析
Animal. 2015 Feb;9(2):218-26. doi: 10.1017/S1751731114002560. Epub 2014 Oct 31.

引用本文的文献

1
Genomic diversity of Cameroonian Gudali and Gudali-cross cattle.喀麦隆古达利牛和古达利杂交牛的基因组多样性
Sci Rep. 2025 Apr 29;15(1):15066. doi: 10.1038/s41598-025-99799-8.
2
Genetic parameters of body weight traits in Mithun (Bos frontalis) using animal model.利用动物模型研究羚牛（Bos frontalis）体重性状的遗传参数。
Trop Anim Health Prod. 2024 Jul 12;56(6):204. doi: 10.1007/s11250-024-04069-w.
3
Whole-Genome Analysis Deciphers Population Structure and Genetic Introgression Among Bovine Species.全基因组分析解析牛物种间的种群结构和基因渐渗

本文引用的文献

1
ESTIMATING F-STATISTICS FOR THE ANALYSIS OF POPULATION STRUCTURE.估计用于群体结构分析的F统计量
Evolution. 1984 Nov;38(6):1358-1370. doi: 10.1111/j.1558-5646.1984.tb05657.x.
2
A genome-wide assessment of genetic diversity and population structure of Korean native cattle breeds.韩国本土牛品种遗传多样性和种群结构的全基因组评估。
BMC Genet. 2016 Oct 20;17(1):139. doi: 10.1186/s12863-016-0444-8.
3
WIDDE: a Web-Interfaced next generation database for genetic diversity exploration, with a first application in cattle.WIDDE：一个用于遗传多样性探索的下一代网络接口数据库，首次应用于牛。
Front Genet. 2022 May 27;13:847492. doi: 10.3389/fgene.2022.847492. eCollection 2022.
4
Mithun (Bos frontalis): the neglected cattle species and their significance to ethnic communities in the Eastern Himalaya - A review.米通牛（大额牛）：被忽视的牛种及其对东喜马拉雅地区民族社区的意义——综述
Anim Biosci. 2021 Nov;34(11):1727-1738. doi: 10.5713/ab.21.0020. Epub 2021 Apr 23.
5
Population demographic history and population structure for Pakistani Nili-Ravi breeding bulls based on SNP genotyping to identify genomic regions associated with male effects for milk yield and body weight.基于 SNP 基因分型的巴基斯坦 Nili-Ravi 种公牛的群体人口历史和群体结构，以鉴定与产奶量和体重的雄性效应相关的基因组区域。
PLoS One. 2020 Nov 24;15(11):e0242500. doi: 10.1371/journal.pone.0242500. eCollection 2020.
6
The complete mitochondrial genome of Indian gaur, Bos gaurus and its phylogenetic implications.印度野牛的完整线粒体基因组及其系统发育意义。
Sci Rep. 2020 Jul 20;10(1):11936. doi: 10.1038/s41598-020-68724-6.
7
Consequences of Domestication on Gut Microbiome: A Comparative Study Between Wild Gaur and Domestic Mithun.驯化对肠道微生物群的影响：野生印度野牛和家养米什米牛的比较研究。
Front Microbiol. 2020 Feb 25;11:133. doi: 10.3389/fmicb.2020.00133. eCollection 2020.
8
Complete mitochondrial genome of Indian mithun, Bos frontalis and its phylogenetic implications.印度野牛（Bos frontalis）的线粒体全基因组及其系统发育意义
Mol Biol Rep. 2019 Apr;46(2):2561-2566. doi: 10.1007/s11033-019-04675-0. Epub 2019 Feb 14.
BMC Genomics. 2015 Nov 14;16:940. doi: 10.1186/s12864-015-2181-1.
4
Genome-wide insights into population structure and genetic history of Tunisian local cattle using the illumina bovinesnp50 beadchip.利用Illumina牛SNP50芯片对突尼斯本地牛的群体结构和遗传历史进行全基因组洞察。
BMC Genomics. 2015 Sep 4;16(1):677. doi: 10.1186/s12864-015-1638-6.
5
Runs of homozygosity and distribution of functional variants in the cattle genome.牛基因组中纯合性连续片段及功能变异的分布
BMC Genomics. 2015 Jul 22;16(1):542. doi: 10.1186/s12864-015-1715-x.
6
Revisiting demographic processes in cattle with genome-wide population genetic analysis.利用全基因组群体遗传分析重新审视牛的种群动态过程。
Front Genet. 2015 Jun 2;6:191. doi: 10.3389/fgene.2015.00191. eCollection 2015.
7
Genome-wide Single Nucleotide Polymorphism Analyses Reveal Genetic Diversity and Structure of Wild and Domestic Cattle in Bangladesh.全基因组单核苷酸多态性分析揭示了孟加拉国野生和家养牛的遗传多样性与结构。
Asian-Australas J Anim Sci. 2014 Oct;27(10):1381-6. doi: 10.5713/ajas.2014.14160.
8
Worldwide patterns of ancestry, divergence, and admixture in domesticated cattle.全球家养牛的祖先、分化及混合模式。
PLoS Genet. 2014 Mar 27;10(3):e1004254. doi: 10.1371/journal.pgen.1004254. eCollection 2014 Mar.
9
Estimating autozygosity from high-throughput information: effects of SNP density and genotyping errors.从高通量信息估计自同型性：SNP 密度和基因分型误差的影响。
Genet Sel Evol. 2013 Oct 29;45(1):42. doi: 10.1186/1297-9686-45-42.
10
Estimates of autozygosity derived from runs of homozygosity: empirical evidence from selected cattle populations.基于纯合子片段推测近交系数：来自特定牛群的实证证据
J Anim Breed Genet. 2013 Aug;130(4):286-93. doi: 10.1111/jbg.12012. Epub 2012 Nov 1.