School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China.
Mar Drugs. 2018 Jul 6;16(7):229. doi: 10.3390/md16070229.
In our continuous chemical investigation on the marine-derived fungus F31-1, two new polyketides dichocetides B-C (, ), two new alkaloids dichotomocejs E-F (, ), and three known fumiquinozalines: scequinadoline A (), quinadoline A (), and scequinadoline E () were discovered from the culture broth and the mycelium in the culture medium, by the addition of l-tryptophan and l-phenylalanine. Their chemical structures were established by one dimensional (1D), two dimensional (2D) nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HR-MS) data. Among them, scequinadoline A () exhibited significant inhibitory activity against dengue virus serotype 2 production by standard plaque assay, equivalent to the positive control andrographlide. Scequinadoline A () possesses the potential for further development as a dengue virus inhibitor.
在对海洋来源真菌 F31-1 的持续化学研究中，从发酵液和发酵培养基中的菌丝体中，通过添加 l-色氨酸和 l-苯丙氨酸，发现了两种新的聚酮类化合物二氢头孢菌素 B-C（1，2）、两种新的生物碱二氢托莫乔辛 E-F（3，4）以及三种已知的夫喹啉嗪类化合物：色喹那丁 A（5）、喹那丁 A（6）和色喹那丁 E（7）。通过一维（1D）、二维（2D）核磁共振（NMR）和高分辨率质谱（HR-MS）数据确定了它们的化学结构。其中，色喹那丁 A（5）在标准蚀斑试验中对登革热病毒血清型 2 的产生表现出显著的抑制活性，与阳性对照化合物穿心莲内酯相当。色喹那丁 A（5）具有作为登革热病毒抑制剂进一步开发的潜力。
