Michaille Jean-Jacques, Piurowski Victoria, Rigot Brooke, Kelani Hesham, Fortman Emily C, Tili Esmerina
BioPerox-IL, UB-INSERM IFR #100, Faculté Gabriel, Université de Bourgogne-Franche Comté, 21000 Dijon, France.
Department of Biology, Franklin College of Arts and Sciences, University of Georgia, Athes, GA 30602, USA.
Medicines (Basel). 2018 Jul 9;5(3):74. doi: 10.3390/medicines5030074.
Resveratrol (trans-3,5,4′-trihydroxystilbene, RSV) is a non-flavonoid dietary polyphenol with antioxidant, anti-inflammatory and anti-cancer properties that is primarily found in red berries. While RSV displays many beneficial effects in vitro, its actual effects in vivo or in animal models remain passionately debated. Recent publications suggest that RSV pleiotropic effects could arise from its capability to regulate the expression and activity of microRNAs, short regulators themselves capable of regulating up to several hundreds of target genes. In particular, RSV increases microRNA expression in different human cell lines, suggesting that at least some of its multiple beneficial properties are through the modulation of expression of this microRNA. Indeed, the expression of microRNA is reduced in certain cancers where is considered to act as a tumor suppressor gene, as well as in other pathologies such as cardiovascular disorders. Target of include genes involved in tumor initiation and/or progression as well as genes involved in pathologies associated with chronic inflammation. Here, we review the direct and indirect effects of RSV on the expression of and its target transcripts, with emphasise on , and their expected health benefits, and argue that elucidating the molecular effects of different classes of natural compounds on the expression of microRNAs should help to identify new therapeutic targets and design new treatments.
白藜芦醇（反式-3,5,4′-三羟基芪，RSV）是一种非类黄酮膳食多酚，具有抗氧化、抗炎和抗癌特性，主要存在于红莓中。虽然RSV在体外显示出许多有益作用，但其在体内或动物模型中的实际效果仍存在激烈争论。最近的出版物表明，RSV的多效性作用可能源于其调节微小RNA（miRNA）表达和活性的能力，这些微小的调节因子本身能够调节多达数百个靶基因。特别是，RSV可增加不同人类细胞系中miRNA的表达，这表明其多种有益特性至少部分是通过调节这种miRNA的表达实现的。事实上，在某些癌症中miRNA的表达会降低，在这些癌症中miRNA被认为起到肿瘤抑制基因的作用，在其他病理状况如心血管疾病中也是如此。miRNA的靶标包括参与肿瘤起始和/或进展的基因以及与慢性炎症相关的病理状况中涉及的基因。在这里，我们综述了RSV对miRNA及其靶转录本表达的直接和间接影响，重点是miRNA，以及它们预期的健康益处，并认为阐明不同类别的天然化合物对miRNA表达的分子影响应有助于识别新的治疗靶点并设计新的治疗方法。
