Kobayashi N, Tamai H, Nagai K, Matsubayashi S, Matsuzuka F, Kuma K, Goto H, Uno H, Sasazuki T, Nagataki S
Nihon Naibunpi Gakkai Zasshi. 1985 Jul 20;61(7):737-43. doi: 10.1507/endocrine1927.61.7_737.
Despite the fact that subacute thyroiditis (SAT) is a common disease, its pathogenesis is still uncertain. At present, viral infection is simply thought to be a possible pathogenic factor. In Caucasians and Chinese, however, a strong association has recently been found between HLA-Bw35 and SAT. Therefore, genetic factors are also thought to participate in the onset of SAT. In this study we have further attempted to clarify the pathogenesis of this disease in this regard.
HLA typing for A, B and C loci (class I antigens) was performed on 89 patients with SAT (males: 7, females: 82) aged from 23 to 66 years, and DR and MT loci (class II antigens) were investigated in 55 patients. In 12 patients, viral antibody titers were measured as soon as possible after onset and two weeks later. The viral antibodies evaluated were those of Influenza A and B, Coxsackie A9, B1, B2, B3, B4, B5 and B6, Echo 3, 7, 11 and 12, Parainfluenza 1, 2, 3 and 4, and Adeno 8 virus. The following results were obtained: In class I HLA typing, the frequency of HLA-Bw35 in SAT was 67.4%, which was significantly (p less than 0.0001) higher than that in the control (14.1%). On the other hand, the frequency of Cw1 in SAT (14.6%) was significantly (p less than 0.01) lower than that of the control (32.1%), and that of Cw3 (65.2%) was significantly (p less than 0.01) higher than that of the control (46.5%). In class II HLA typing, the frequency of DRw8 in SAT was 38.2%, which was significantly (p less than 0.05) higher than that of the control (21.9%). Other antigens showed no significant changes.(ABSTRACT TRUNCATED AT 250 WORDS)
尽管亚急性甲状腺炎（SAT）是一种常见疾病，但其发病机制仍不明确。目前，病毒感染仅被认为是一种可能的致病因素。然而，在白种人和中国人中，最近发现HLA - Bw35与SAT之间存在密切关联。因此，遗传因素也被认为参与了SAT的发病过程。在本研究中，我们进一步试图在这方面阐明该疾病的发病机制。
对89例年龄在23至66岁之间的SAT患者（男性7例，女性82例）进行了A、B和C位点（I类抗原）的HLA分型，并对55例患者进行了DR和MT位点（II类抗原）的研究。在12例患者中，发病后尽快及两周后测量了病毒抗体滴度。所评估的病毒抗体包括甲型和乙型流感病毒、柯萨奇A9、B1、B2、B3、B4、B5和B6、埃可病毒3、7、11和12、副流感病毒1、2、3和4以及腺病毒8型。获得了以下结果：在I类HLA分型中，SAT患者中HLA - Bw35的频率为67.4%，显著高于对照组（14.1%）（p<0.0001）。另一方面，SAT患者中Cw1的频率（14.6%）显著低于对照组（32.1%）（p<0.01），而Cw3的频率（65.2%）显著高于对照组（46.5%）（p<0.01）。在II类HLA分型中，SAT患者中DRw8的频率为38.2%，显著高于对照组（21.9%）（p<0.05）。其他抗原无显著变化。（摘要截断于250字）
