Ohsako N, Tamai H, Sudo T, Mukuta T, Tanaka H, Kuma K, Kimura A, Sasazuki T
Ohsako Hospital, Kagoshima, Japan.
J Clin Endocrinol Metab. 1995 Dec;80(12):3653-6. doi: 10.1210/jcem.80.12.8530615.
We investigated human leukocyte antigen (HLA) class I and class II antigens in 56 Japanese patients with subacute thyroiditis (SAT) who visited our out-patient clinic between 1988 and 1990. We found SAT to be associated with not only HLA-B35 (40 patients; P < 0.000001; relative risk, 18.02), but also with HLA-B67 antigens (9 patients; P < 0.00001; relative risk, 11.20). No heterozygotes of HLA-B35 or HLA-B67 were found in any of the 56 patients with SAT. Either HLA-B35 or HLA-B67 antigen is found in 87% of patients with SAT. When season of onset and clinical course of SAT were compared in the 49 patients with HLA-B35-positive SAT (B35-SAT) and HLA-B67-positive SAT (B67-SAT), we were able to identify certain characteristics: 1) B67-SAT often followed the course from transient thyrotoxicosis to a hypothyroid phase to a euthyroid phase [6 of 9 B67-SAT (67%) vs. 10 of 40 B35-SAT (25%); P < 0.05]; and 2) B67-SAT occurred mostly during the summer or autumn and at a higher rate than did B35-SAR [8 of 9 B67-SAT (89%) vs. 17 of 40 B35-SAT (43%)], whereas B35-SAT occurred throughout the year. We conclude that there are at least two types of SAT that can be classified by association with either HLA-B35 or HLA-B67 antigens.
我们对1988年至1990年间到我院门诊就诊的56例日本亚急性甲状腺炎（SAT）患者进行了人类白细胞抗原（HLA）I类和II类抗原研究。我们发现SAT不仅与HLA - B35相关（40例患者；P < 0.000001；相对风险，18.02），还与HLA - B67抗原相关（9例患者；P < 0.00001；相对风险，11.20）。在56例SAT患者中未发现HLA - B35或HLA - B67的杂合子。87%的SAT患者存在HLA - B35或HLA - B67抗原。当比较49例HLA - B35阳性SAT（B35 - SAT）和HLA - B67阳性SAT（B67 - SAT）患者的发病季节和临床病程时，我们发现了一些特点：1）B67 - SAT常经历从短暂甲状腺毒症到甲状腺功能减退期再到甲状腺功能正常期的过程[9例B67 - SAT中有6例（67%），而40例B35 - SAT中有10例（25%）；P < 0.05]；2）B67 - SAT大多发生在夏季或秋季，发生率高于B35 - SAT[9例B67 - SAT中有8例（89%），而40例B35 - SAT中有17例（43%）]，而B35 - SAT全年均可发生。我们得出结论，至少有两种类型的SAT可根据与HLA - B35或HLA - B67抗原的关联进行分类。
