Evans A S
IARC Sci Publ. 1985(60):197-204.
Events surrounding infection and disease in infectious mononucleosis are a model for epidemiological factors that may affect the phase of initiation, the phase of promotion and the phase of tumour development in African Burkitt's lymphoma (BL). Consideration of the circumstances of early Epstein-Barr virus (EBV) infection as the initiator, and of malaria as the promoter, of African BL reveal some shortcomings in the evidence incriminating malaria. Possible factors leading to the emergence of the clinical tumour suggest that other factors may be involved. The absence of EBV and malarial infection in some cases of American BL indicate that they are neither necessary nor sufficient causes of the tumour in all settings.
传染性单核细胞增多症中围绕感染和疾病的事件是一个流行病学因素模型，这些因素可能影响非洲伯基特淋巴瘤（BL）起始阶段、促进阶段和肿瘤发展阶段。将早期爱泼斯坦-巴尔病毒（EBV）感染视为非洲BL的起始因素，而疟疾视为促进因素，对这些情况的考量揭示了将疟疾认定为罪魁祸首的证据存在一些缺陷。导致临床肿瘤出现的可能因素表明可能涉及其他因素。美国BL的某些病例中不存在EBV和疟疾感染，这表明它们在所有情况下都既不是肿瘤的必要病因，也不是充分病因。
