Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Boston University School of Medicine, Boston, MA, USA.
Acta Paediatr. 2018 Nov;107(11):1932-1936. doi: 10.1111/apa.14494. Epub 2018 Aug 7.
To evaluate the relationship between corticotropin-releasing hormone (CRH) expression in the placenta and the risk of school-related dysfunctions at the age of 10 years among children born extremely preterm (EP).
Corticotropin-releasing hormone expression was measured in the placenta of 761 EP children, who had the following assessments at the age of 10 years: Differential Ability Scales, Oral and Written Language Scales, the Wechsler Individual Achievement Test-III, NEPSY-II and the Child Symptom Inventory-4. We evaluated whether lowest and highest quartiles of CRH mRNA were associated with undesirable scores on these assessments. With 272 evaluations, we would expect 14 to be significant at p < 0.05.
Only 16 associations were statistically significant. On the other hand, seven of these were social limitations among girls whose placenta CRH mRNA was in the top quartile. Adjusting for delivery indication or restricting the sample to one delivery indication group resulted in few differences.
Overall, placenta CRH mRNA concentrations in the top or bottom quartiles were not associated with increased risks of dysfunctions 10 years later. Girls whose placenta CRH expression was in the top quartile, however, were at increased risk of seven indicators/correlates of social limitations.
评估胎盘促肾上腺皮质激素释放激素（CRH）表达与 10 岁时极早产儿（EP）发生与学校相关功能障碍风险的关系。
对 761 名 EP 儿童的胎盘进行促肾上腺皮质激素释放激素表达测量，这些儿童在 10 岁时进行了以下评估：差异能力量表、口语和书面语言量表、韦氏个体成就测验-III、NEPSY-II 和儿童症状清单-4。我们评估了 CRH mRNA 的最低和最高四分位数是否与这些评估的不良评分相关。用 272 次评估，我们预计在 p < 0.05 时有 14 次有统计学意义。
只有 16 项关联具有统计学意义。另一方面，在胎盘 CRH mRNA 处于最高四分位的女孩中，有 7 项是社会限制。调整分娩指征或将样本限制在一个分娩指征组，结果差异不大。
总体而言，胎盘 CRH mRNA 浓度在最高或最低四分位数与 10 年后功能障碍风险增加无关。然而，胎盘 CRH 表达处于最高四分位的女孩，其社会限制的七个指标/相关因素的风险增加。
